SCHEMBL4677176

SCHEMBL4677176

O=C(O)CC(C(=O)O)N1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1

nearest known ligand 0.58

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
SLC6A9 P48067 1/20 0.45
HSD17B10 Q99714 2/20 0.42
ALB P02768 1/20 0.35
POLB P06746 1/20 0.35
MAPK1 P28482 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
TACR1 P25103 3/20 0.34
MAPT P10636 1/20 0.34
ALDH1A1 P00352 1/20 0.33
TP53 P04637 1/20 0.33
TDP1 Q9NUW8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2779265 1.00 SLC6A9 (0.45) SLC6A9HSD17B10ALBPOLBMAPK1
SCHEMBL15780321 1.00 SLC6A9 (0.45) SLC6A9HSD17B10ALBPOLBMAPK1
SCHEMBL25137537 0.92 SLC6A9 (0.40) SLC6A9HSD17B10ALBPOLBMAPK1
SCHEMBL16922658 0.92 MAPT (0.44) SLC6A9HSD17B10TACR1MAPTALDH1A1
SCHEMBL17190336 0.92 MAPT (0.44) SLC6A9HSD17B10TACR1MAPTALDH1A1
SCHEMBL15444498 0.89 SLC6A9 (0.38) SLC6A9HSD17B10ALBPOLBMAPK1
SCHEMBL12768265 0.89 CHRM5 (0.40) SLC6A9HSD17B10ALBPOLBMAPK1
SCHEMBL8562008 0.88 HSD17B10 (0.43) HSD17B10POLBMAPK1L3MBTL1MAPT
SCHEMBL11713448 0.88 HSD17B10 (0.43) HSD17B10POLBMAPK1L3MBTL1MAPT
SCHEMBL17706711 0.88 HSD17B10 (0.43) HSD17B10POLBMAPK1L3MBTL1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230120220-A1 PROCESS FOR SITE-SPECIFIC MODIFICATION OF AN ANTIBODY Orano Mining (FR) 2023-04-20 US disclosed
US-20220184217-A1 HSP90-BINDING CONJUGATES AND FORMULATIONS THEREOF Fusion Pharmaceuticals Inc. (CA) 2022-06-16 US disclosed
WO-2021202830-A2 HSP90-BINDING CONJUGATES AND FORMULATIONS THEREOF TARVEDA THERAPEUTICS, INC. (US) 2021-10-07 WO disclosed
US-20210145971-A1 HSP90-TARGETING CONJUGATES AND FORMULATIONS THEREOF Fusion Pharmaceuticals Inc. (CA) 2021-05-20 US disclosed
US-10874753-B2 Radiopharmaceutical conjugate of a metabolite and an EPR agent, for targeting tumour cells THE SOUTH AFRICAN NUCLEAR ENERGY CORPORATION LIMITED (ZA) 2020-12-29 US disclosed
WO-2020205948-A1 HSP90-BINDING CONJUGATES AND FORMULATIONS THEREOF TARVEDA THERAPEUTICS, INC. (US) 2020-10-08 WO disclosed
WO-2019195384-A1 HSP90-TARGETING CONJUGATES AND FORMULATIONS THEREOF TARVEDA THERAPEUTICS, INC. (US) 2019-10-10 WO disclosed
US-20170296684-A1 RADIOPHARMACEUTICAL CONJUGATE UNIVERSITY OF CAPE TOWN (ZA) 2017-10-19 US disclosed
US-20170296684-A1 RADIOPHARMACEUTICAL CONJUGATE UNIVERSITY OF CAPE TOWN (ZA) 2017-10-19 US disclosed
US-9764048-B2 Targeted molecular imaging probe and method for in vivo molecular imaging SHEN BAOZHONG (CN) 2017-09-19 US disclosed
WO-2016046793-A2 RADIOPHARMACEUTICAL CONJUGATE THE SOUTH AFRICAN NUCLEAR ENERGY CORPORATION LIMITED (ZA) 2016-03-31 WO disclosed
US-20150202335-A1 TARGETED MOLECULAR IMAGING PROBE AND METHOD FOR IN VIVO MOLECULAR IMAGING SHEN BAOZHONG (CN) 2015-07-23 US disclosed
EP-1898962-A1 GASTRIN RELEASING PEPTIDE COMPOUNDS Bracco Imaging, S.P.A. (IT) 2008-03-19 EP disclosed
WO-2007002500-A1 GASTRIN RELEASING PEPTIDE COMPOUNDS BRACCO IMAGING S.P.A. (IT) 2007-01-04 WO disclosed
WO-2004062574-A9 IMPROVED LINKERS FOR RADIOPHARMACEUTICAL COMPOUNDS BRACCO IMAGING SPA (IT) 2005-05-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10874753-B2 Radiopharmaceutical conjugate of a metabolite and an EPR agent, for targeting tumour cells EPRS1, FOLH1, SLC46A1 SLC6A9 1357/4885HSD17B10 4082/4885ALB 2301/4885
US-20230120220-A1 PROCESS FOR SITE-SPECIFIC MODIFICATION OF AN ANTIBODY OGA, GANAB, TGM1 SLC6A9 1477/4885HSD17B10 4132/4885ALB 209/4885
US-20150202335-A1 TARGETED MOLECULAR IMAGING PROBE AND METHOD FOR IN VIVO MOLECULAR IMAGING GJB2, GJA1, GAP43 SLC6A9 3051/4885HSD17B10 3433/4885ALB 2293/4885
US-20220184217-A1 HSP90-BINDING CONJUGATES AND FORMULATIONS THEREOF HSP90AB1, HSP90B1, HSP90AA1 SLC6A9 2479/4885HSD17B10 1604/4885ALB 671/4885
US-20170296684-A1 RADIOPHARMACEUTICAL CONJUGATE FOLH1, EPRS1, FOLR1 SLC6A9 1573/4885HSD17B10 3900/4885ALB 2165/4885
US-20210145971-A1 HSP90-TARGETING CONJUGATES AND FORMULATIONS THEREOF HSP90AB1, HSP90B1, HSP90AA1 SLC6A9 2667/4885HSD17B10 1613/4885ALB 758/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.