Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.43 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4903979 | 0.90 | MAPT (0.46) | HTR1AADRA1DADRA1AADRA1BMAPT | |
| SCHEMBL9237762 | 0.89 | BCHE (0.49) | HTR1AADRA1DADRA1AADRA1BL3MBTL1 | |
| SCHEMBL4157654 | 0.88 | ABCB1 (0.49) | HTR1AADRA1DADRA1AADRA1BNPC1 | |
| SCHEMBL15088139 | 0.81 | HTR1A (0.38) | HTR1AADRA1DADRA1AADRA1BMAPT | |
| SCHEMBL30963127 | 0.80 | ALDH1A1 (0.37) | PDCD1CD274MAPTL3MBTL1ERN1 | |
| SCHEMBL4111524 | 0.80 | ALDH1A1 (0.37) | PDCD1CD274MAPTL3MBTL1ERN1 | |
| SCHEMBL4688192 | 0.79 | L3MBTL1 (0.50) | HTR1AADRA1DADRA1AADRA1BMAPT | |
| SCHEMBL1178876 | 0.77 | LTA4H (0.58) | HTR1AMAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL4681700 | 0.77 | RXRA (0.50) | HTR1AADRA1DADRA1AADRA1BNPC1 | |
| SCHEMBL4684239 | 0.77 | MGAM (0.44) | HTR1AADRA1DADRA1AADRA1BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1973906-A1 | HYDROXYDIHYDROPYRIDOPY RAZINE-1,8-DIONES AND METHODS FOR INHIBITING HIV INTEGRASE | Virochem Pharma Inc. (CA) | 2008-10-01 | — | — | EP | disclosed |
| WO-2006066414-A1 | HYDROXYDIHYDROPYRIDOPY RAZINE-1,8-DIONES AND METHODS FOR INHIBITING HIV INTEGRASE | VIROCHEM PHARMA INC. (CA) | 2006-06-29 | — | — | WO | disclosed |