SCHEMBL4692627

SCHEMBL4692627

COc1cccc(C(=O)N2CC3CN(C(CC(N)=O)c4ccc(C)c(Cl)c4)CC3C2)c1OC

nearest known ligand 0.50

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 3/20 0.50
HCRTR2 O43614 3/20 0.50
CBX7 O95931 6/20 0.44
ALDH1A1 P00352 7/20 0.42
LMNA P02545 4/20 0.42
KDM4E B2RXH2 3/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
NPSR1 Q6W5P4 2/20 0.42
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42
HTT P42858 2/20 0.41
POLB P06746 1/20 0.41
HIF1A Q16665 1/20 0.41
GAA P10253 3/20 0.40
HSD11B1 P28845 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4691302 0.94 HCRTR1 (0.42) HCRTR1HCRTR2CBX7SMN1; SMN2NPC1
SCHEMBL4693952 0.93 HCRTR1 (0.50) HCRTR1HCRTR2NPC1POLB
SCHEMBL4691405 0.92 HCRTR1 (0.48) HCRTR1HCRTR2ALDH1A1KDM4ENPC1
SCHEMBL4693896 0.90 HCRTR1 (0.47) HCRTR1HCRTR2ALDH1A1LMNAKDM4E
SCHEMBL4694350 0.86 KCNK3 (0.42) HCRTR1HCRTR2ALDH1A1LMNAKDM4E
SCHEMBL4694354 0.86 P2RX7 (0.44) HCRTR1HCRTR2
SCHEMBL4691868 0.86 HCRTR1 (0.47) HCRTR1HCRTR2ALDH1A1LMNASMN1; SMN2
SCHEMBL4692886 0.86 ALDH1A1 (0.42) HCRTR1HCRTR2ALDH1A1NPSR1HTT
SCHEMBL4692334 0.85 HCRTR1 (0.51) HCRTR1HCRTR2LMNASMN1; SMN2NPSR1
SCHEMBL4695901 0.85 HCRTR2 (0.47) HCRTR1HCRTR2HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1761542-B1 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS HOFFMANN LA ROCHE (CH) 2008-01-02 EP claimed
EP-1761542-A2 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS F.HOFFMANN-LA ROCHE AG (CH) 2007-03-14 EP claimed
WO-2005121145-A2 OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS F. HOFFMANN-LA ROCHE AG (CH) 2005-12-22 WO claimed
EP-1761542-B1 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS HOFFMANN LA ROCHE (CH) 2008-01-02 EP disclosed
EP-1761542-A2 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS F.HOFFMANN-LA ROCHE AG (CH) 2007-03-14 EP disclosed
WO-2005121145-A2 OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS F. HOFFMANN-LA ROCHE AG (CH) 2005-12-22 WO disclosed