Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 7/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 7/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4694248 | 0.86 | ALDH1A1 (0.39) | TNFHCRTR1HCRTR2GAACCR5 | |
| SCHEMBL4695935 | 0.86 | HCRTR2 (0.47) | TNFHCRTR1HCRTR2HPGDALDH1A1 | |
| SCHEMBL4692886 | 0.86 | ALDH1A1 (0.42) | TNFHCRTR1HCRTR2CCR5HPGD | |
| SCHEMBL4695956 | 0.85 | HCRTR1 (0.37) | TNFHCRTR1HCRTR2CCR5HPGD | |
| SCHEMBL4690680 | 0.85 | HCRTR1 (0.42) | TNFHCRTR1HCRTR2HPGDALDH1A1 | |
| SCHEMBL4690738 | 0.85 | HCRTR1 (0.46) | TNFHCRTR1HCRTR2HPGDALDH1A1 | |
| SCHEMBL4692692 | 0.85 | HCRTR1 (0.45) | TNFHCRTR1HCRTR2TSHRALDH1A1 | |
| SCHEMBL4694354 | 0.84 | P2RX7 (0.44) | TNFHCRTR1HCRTR2 | |
| SCHEMBL4691868 | 0.84 | HCRTR1 (0.47) | TNFHCRTR1HCRTR2CCR5ALDH1A1 | |
| SCHEMBL4693718 | 0.84 | TSHR (0.38) | TNFHCRTR1HCRTR2TSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |