Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 10/20 | 0.44 |
| ▸ | CTSS | P25774 | 10/20 | 0.44 |
| ▸ | CTSB | P07858 | 9/20 | 0.44 |
| ▸ | CTSK | P43235 | 8/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | MAP2 | P11137 | 2/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4705295 | 0.84 | CTSL (0.45) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4701371 | 0.81 | CTSL (0.33) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4700109 | 0.78 | CTSL (0.38) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4699567 | 0.77 | CTSK (0.44) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4703612 | 0.76 | CTSS (0.34) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4701830 | 0.76 | CTSK (0.37) | CTSLCTSSCTSBCTSK | |
| SCHEMBL6801548 | 0.75 | CTSS (0.35) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4703746 | 0.75 | OPRM1 (0.37) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4699645 | 0.75 | CTSL (0.77) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4756631 | 0.74 | RET (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1372655-B1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2008-10-01 | — | — | EP | disclosed |