Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 4/20 | 0.40 |
| ▸ | CTSK | P43235 | 4/20 | 0.40 |
| ▸ | CTSS | P25774 | 3/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 6/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 6/20 | 0.36 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4699525 | 0.91 | CTSL (0.38) | CTSLCTSKCTSSMKNK1CTSB | |
| SCHEMBL4701632 | 0.86 | FNTA (0.34) | — | |
| SCHEMBL4703027 | 0.84 | CTSK (0.31) | CTSLCTSKCTSSCTSB | |
| SCHEMBL4705219 | 0.83 | F11 (0.32) | — | |
| SCHEMBL4701995 | 0.83 | CTSK (0.37) | CTSLCTSKCTSSCTSBLMNA | |
| SCHEMBL4699905 | 0.79 | CTSS (0.41) | CTSLCTSKCTSSCTSBSYK | |
| SCHEMBL4698340 | 0.79 | — | — | |
| SCHEMBL4701807 | 0.78 | TGFBR1 (0.36) | CTSLCTSKCTSSCTSB | |
| SCHEMBL4703327 | 0.78 | CTSL (0.46) | CTSLCTSKCTSSCTSB | |
| SCHEMBL4703250 | 0.78 | CTSL (0.46) | CTSLCTSKCTSSCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1372655-B1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2008-10-01 | — | — | EP | disclosed |