Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 15/20 | 0.37 |
| ▸ | CTSS | P25774 | 11/20 | 0.37 |
| ▸ | CTSL | P07711 | 9/20 | 0.36 |
| ▸ | CTSB | P07858 | 7/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4701632 | 0.88 | FNTA (0.34) | — | |
| SCHEMBL4699525 | 0.87 | CTSL (0.38) | CTSKCTSSCTSLCTSB | |
| SCHEMBL4703027 | 0.87 | CTSK (0.31) | CTSKCTSSCTSLCTSB | |
| SCHEMBL4703631 | 0.85 | CTSL (0.39) | CTSKCTSSCTSLCTSBCA2 | |
| SCHEMBL4702728 | 0.84 | RORC (0.35) | CTSKCTSSCTSLCTSB | |
| SCHEMBL4701440 | 0.83 | CTSL (0.40) | CTSKCTSSCTSLCTSBSYK | |
| SCHEMBL4705219 | 0.82 | F11 (0.32) | — | |
| SCHEMBL4699905 | 0.81 | CTSS (0.41) | CTSKCTSSCTSLCTSBSYK | |
| SCHEMBL4703250 | 0.81 | CTSL (0.46) | CTSKCTSSCTSLCTSB | |
| SCHEMBL4701807 | 0.81 | TGFBR1 (0.36) | CTSKCTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1372655-B1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2008-10-01 | — | — | EP | disclosed |