Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORB | Q92753 | 2/20 | 0.49 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PRKCG | P05129 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4705134 | 0.90 | RORB (0.45) | RORBJAK2JAK1TDO2IDO1 | |
| SCHEMBL4759328 | 0.88 | RORB (0.43) | RORBSMN1; SMN2P2RX7PTGDR2RORC | |
| SCHEMBL4705301 | 0.84 | RORB (0.42) | RORBJAK2JAK1RPS6KB1P2RX7 | |
| SCHEMBL4708293 | 0.84 | RORB (0.40) | RORBP2RX7RORC | |
| SCHEMBL4707219 | 0.84 | RORB (0.48) | RORBTDO2IDO1MAPK1CYP19A1 | |
| SCHEMBL4706973 | 0.84 | RORB (0.44) | RORBSMN1; SMN2MAPTP2RX7KMT2A | |
| SCHEMBL4707264 | 0.83 | RORB (0.49) | RORBTDO2IDO1SMN1; SMN2VNN1 | |
| SCHEMBL4706958 | 0.82 | RORB (0.42) | RORBP2RX7RORCCYP2C9 | |
| SCHEMBL4709738 | 0.81 | RORB (0.42) | RORBRPS6KA3P2RX7PTGDR2RORC | |
| SCHEMBL4707224 | 0.79 | RORB (0.44) | RORBTDO2IDO1SMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501809-B1 | TRIAZOLE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-01-16 | — | — | EP | disclosed |