Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 3/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | MPO | P05164 | 3/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | IDO1 | P14902 | 3/20 | 0.40 |
| ▸ | HTR2A | P28223 | 7/20 | 0.38 |
| ▸ | HTR2C | P28335 | 6/20 | 0.38 |
| ▸ | HTR2B | P41595 | 4/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29445177 | 0.87 | GPR84 (0.65) | KDM4EMEN1ALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL27517077 | 0.87 | CSNK2A1 (0.56) | KDM4EMEN1ALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL8222885 | 0.87 | GPR84 (0.65) | KDM4EMEN1ALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL21131303 | 0.83 | GPR84 (0.50) | KDM4EMEN1ALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL24143606 | 0.79 | MPO (0.56) | KMT2AGPR84HTR1ACSNK2A1MPO | |
| SCHEMBL3475267 | 0.78 | HTR2A (0.59) | CYP3A4CYP2D6TSHRKMT2AGPR84 | |
| SCHEMBL32677621 | 0.76 | GPR84 (0.50) | KMT2AGPR84HTR1ACSNK2A1MPO | |
| SCHEMBL1196112 | 0.76 | HTR1A (0.75) | KDM4EMEN1ALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL4720456 | 0.75 | CSNK2A1 (0.77) | KMT2AGPR84HTR1ACSNK2A1MPO | |
| SCHEMBL6031494 | 0.74 | KDM4E (0.60) | KDM4EMEN1ALDH1A1CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660484-B1 | METHYL INDOLES AND METHYL PYRROLOPYRIDINES AS ALPHA-1 ADRENERGIC AGONISTS | HOFFMANN LA ROCHE (CH) | 2008-08-27 | — | — | EP | disclosed |
| EP-1660484-B1 | METHYL INDOLES AND METHYL PYRROLOPYRIDINES AS ALPHA-1 ADRENERGIC AGONISTS | HOFFMANN LA ROCHE (CH) | 2008-08-27 | — | — | EP | disclosed |
| CN-100378097-C | Methyl indoles and methyl pyrrolopyridines as alph-1 adrenergic agonists | HOFFMANN LA ROCHE (CH) | 2008-04-02 | — | — | CN | disclosed |
| CN-1784397-A | Methyl indoles and methyl pyrrolopyridines as alph-1 adrenergic agonists | HOFFMANN LA ROCHE (CH) | 2006-06-07 | — | — | CN | disclosed |
| EP-1660484-A1 | METHYL INDOLES AND METHYL PYRROLOPYRIDINES AS ALPHA-1 ADRENERGIC AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-05-31 | — | — | EP | disclosed |
| US-6979696-B2 | Method for detecting a gram-negative bacterial autoinducer molecule | ROCHE PALO ALTO LLC (US) | 2005-12-27 | — | — | US | disclosed |
| US-6852860-B2 | Method for making piperidone ketals using polyphosphoric acid | WEYERHAEUSER COMPANY (US) | 2005-02-08 | — | — | US | disclosed |
| WO-2004099189-A1 | METHYL INDOLES AND METHYL PYRROLOPYRIDINES AS ALPH-1 ADRENERGIC AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-11-18 | — | — | WO | disclosed |
| US-20040224973-A1 | Substituted indoles as alpha-1 agonists | ROCHE PALO ALTO LLC | 2004-11-11 | — | — | US | disclosed |
| US-20040192920-A1 | Method for making piperidone ketals using polyphosphoric acid | WEYERHAUSER COMPANY | 2004-09-30 | — | — | US | disclosed |
| EP-1457491-A1 | Method for making piperidone ketals using polyphosphoric acid | Weyerhaeuser Company (US) | 2004-09-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040224973-A1 | Substituted indoles as alpha-1 agonists | ADRA1A, ADRB1, ADRA1D | KDM4E 3362/4885MEN1 1123/4885ALDH1A1 408/4885 |
| US-20040192920-A1 | Method for making piperidone ketals using polyphosphoric acid | PNKP, DCTPP1, PCBP1 | KDM4E 344/4885MEN1 2878/4885ALDH1A1 800/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.