Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.33 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4734073 | 0.89 | CHIA (0.33) | HPGDKDM4ETP53LMNAHSD17B10 | |
| SCHEMBL4739290 | 0.87 | PDE10A (0.33) | NAMPTHCN1HCN4 | |
| SCHEMBL4739132 | 0.85 | KDM4E (0.40) | KDM4ERXFP1MAPT | |
| SCHEMBL4737070 | 0.84 | ALDH1A1 (0.36) | HPGDALDH1A1KDM4EKMT2AMAPT | |
| SCHEMBL4739802 | 0.84 | NPC1 (0.32) | TP53 | |
| SCHEMBL4737853 | 0.84 | PTGES (0.38) | PPARGNR2E3NCOR2CACNA1GCACNA1H | |
| SCHEMBL4244256 | 0.84 | ALDH1A1 (0.39) | HPGDALDH1A1KDM4ENAMPTTP53 | |
| SCHEMBL4738609 | 0.81 | DHODH (0.36) | HPGDALDH1A1KDM4ETP53KMT2A | |
| SCHEMBL4738895 | 0.81 | KMT2A (0.36) | HPGDALDH1A1KDM4EHTTKMT2A | |
| SCHEMBL4782354 | 0.79 | KDM4E (0.32) | ALDH1A1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008071765-A1 | PHARMACEUTICALLY ACTIVE SPIRO-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | NYCOMED GMBH (DE) | 2008-06-19 | — | — | WO | claimed |