Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.30 |
| ▸ | HCN1 | O60741 | 1/20 | 0.30 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4734073 | 0.89 | CHIA (0.33) | NPC1RAB9AHCN1HCN4 | |
| SCHEMBL4737025 | 0.87 | HPGD (0.40) | NAMPTHCN1HCN4 | |
| SCHEMBL4739132 | 0.86 | KDM4E (0.40) | NPC1RAB9A | |
| SCHEMBL4739802 | 0.86 | NPC1 (0.32) | NPC1RAB9A | |
| SCHEMBL4737853 | 0.85 | PTGES (0.38) | HCN1HCN4 | |
| SCHEMBL4737882 | 0.84 | RAB9A (0.35) | NPC1RAB9A | |
| SCHEMBL4738609 | 0.83 | DHODH (0.36) | NPC1RAB9A | |
| SCHEMBL4782354 | 0.82 | KDM4E (0.32) | — | |
| SCHEMBL4737070 | 0.81 | ALDH1A1 (0.36) | NPC1RAB9A | |
| SCHEMBL4737057 | 0.79 | OPRL1 (0.36) | PDE10ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008071765-A1 | PHARMACEUTICALLY ACTIVE SPIRO-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | NYCOMED GMBH (DE) | 2008-06-19 | — | — | WO | claimed |