Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 4/20 | 0.38 |
| ▸ | HCN1 | O60741 | 3/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.32 |
| ▸ | MTTP | P55157 | 2/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.31 |
| ▸ | CFTR | P13569 | 1/20 | 0.31 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.31 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.31 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.31 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.30 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.30 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4734073 | 0.89 | CHIA (0.33) | HCN1NR3C1P2RX7HCN4 | |
| SCHEMBL4739132 | 0.87 | KDM4E (0.40) | PTGESP2RX7NAPEPLD | |
| SCHEMBL4739802 | 0.86 | NPC1 (0.32) | — | |
| SCHEMBL4739290 | 0.85 | PDE10A (0.33) | HCN1HCN4 | |
| SCHEMBL4737025 | 0.84 | HPGD (0.40) | HCN1CACNA1GCACNA1HCACNA1IHCN4 | |
| SCHEMBL4738609 | 0.83 | DHODH (0.36) | — | |
| SCHEMBL4737882 | 0.83 | RAB9A (0.35) | — | |
| SCHEMBL4737070 | 0.81 | ALDH1A1 (0.36) | GABRA5 | |
| SCHEMBL4782354 | 0.81 | KDM4E (0.32) | — | |
| SCHEMBL4734384 | 0.79 | KMT2A (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008071765-A1 | PHARMACEUTICALLY ACTIVE SPIRO-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | NYCOMED GMBH (DE) | 2008-06-19 | — | — | WO | claimed |