Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of P-Nitrophenylphosphate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 known ✓ | P00915 | 5/20 | 0.96 |
| ▸ | CA2 known ✓ | P00918 | 4/20 | 0.96 |
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.54 |
| ▸ | CA12 known ✓ | O43570 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.76 |
| ▸ | CES1 | P23141 | 1/20 | 0.76 |
| ▸ | BCHE | P06276 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| P-Nitrophenylphosphate SCHEMBL35320 | 0.98 | CA1 (1.00) | CA1CA2CES2CES1BCHE | |
| P-Nitrophenylphosphate SCHEMBL28027358 | 0.98 | CA1 (1.00) | CA1CA2CES2CES1BCHE | |
| P-Nitrophenylphosphate SCHEMBL28396311 | 0.96 | CA1 (0.96) | CA1CA2CES2CES1BCHE | |
| P-Nitrophenylphosphate SCHEMBL3211717 | 0.96 | CA1 (0.96) | CA1CA2CES2CES1BCHE | |
| P-Nitrophenylphosphate SCHEMBL11322616 | 0.96 | CA1 (0.96) | CA1CA2CES2CES1BCHE | |
| P-Nitrophenylphosphate SCHEMBL11152111 | 0.96 | CA1 (0.96) | CA1CA2CES2CES1BCHE | |
| P-Nitrophenylphosphate SCHEMBL8381854 | 0.96 | CA1 (0.96) | CA1CA2CES2CES1BCHE | |
| P-Nitrophenylphosphate SCHEMBL3095493 | 0.96 | CA1 (0.96) | CA1CA2CES2CES1BCHE | |
| P-Nitrophenylphosphate SCHEMBL3097581 | 0.96 | CA1 (0.96) | CA1CA2CES2CES1BCHE | |
| P-Nitrophenylphosphate SCHEMBL11322606 | 0.96 | CA1 (0.96) | CA1CA2CES2CES1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106754817-B | Expression method of recombinant autotaxin | 山西省生物研究院有限公司 | 2021-02-05 | — | — | CN | claimed |
| CN-106754817-A | A kind of expression for recombinating autocrine motility factor | 山西省生物研究所 | 2017-05-31 | — | — | CN | claimed |
| CN-102297962-A | Kit for detecting alkaline phosphatase | — | 2011-12-28 | — | — | CN | claimed |
| CN-111596051-B | Method for acquiring information of measured substance and method for capturing measured substance | 希森美康株式会社 | 2025-05-16 | — | — | CN | disclosed |
| CN-118718951-A | Paranitrophosphate disodium production system | 深圳瑞亚力集团有限公司 | 2024-10-01 | — | — | CN | disclosed |
| EP-3341112-B1 | METHODS AND COMPOSITIONS FOR PROTEIN PURIFICATION AND ENZYME REACTION | UNIV CALIFORNIA (US) | 2023-11-08 | — | — | EP | disclosed |
| CN-113552107-B | Application of cellulose-based carbon quantum dots in organophosphorus pesticide detection | 齐鲁工业大学 | 2023-05-26 | — | — | CN | disclosed |
| CN-115011337-B | Boric acid functionalized carbon dot and preparation method and application thereof | 齐鲁工业大学 | 2023-05-05 | — | — | CN | disclosed |
| CN-115093978-A | Tobacco endophytic fungus secreting resveratrol and application thereof in biological control | 中国农业科学院烟草研究所(中国烟草总公司青州烟草研究所) | 2022-09-23 | — | — | CN | disclosed |
| WO-2021060496-A1 | METHOD FOR IMPROVING PHOTOCLEAVAGE EFFICIENCY OF PHOTOCLEAVABLE LINKER, PHOTOCLEAVABLE LINKER-BOUND MAGNETIC PARTICLE, AND MEASUREMENT METHOD FOR MEASURING TARGET SUBSTANCE AND KIT FOR USE THEREWITH | 富士レビオ株式会社 | 2021-04-01 | — | — | WO | disclosed |
| CN-106754817-B | Expression method of recombinant autotaxin | 山西省生物研究院有限公司 | 2021-02-05 | — | — | CN | disclosed |
| EP-0061731-B2 | NOVEL PHOSPHORIC ESTER AND A METHOD FOR QUANTITATIVE ANALYSIS OF AN ALKALINE PHOSPHATASE USING THE SAME AS A SUBSTRATE | Fuji Photo Film Co., Ltd. (JP) | 1992-01-29 | — | — | EP | disclosed |
| EP-0265519-A4 | ELECTROCHEMILUMINESCENT ASSAYS. | IGEN INC (US) | 1990-05-14 | — | — | EP | disclosed |
| US-4797476-A | Mono-4-arylazoaryl phosphoric esters | FUJI SHASHIN FILM KABUSHIKI KAISHA (JP) | 1989-01-10 | — | — | US | disclosed |
| EP-0269979-A2 | Analytical element for measuring alkaline phosphatase | KONICA CORPORATION (JP) | 1988-06-08 | — | — | EP | disclosed |
| EP-0265519-A1 | ELECTROCHEMILUMINESCENT ASSAYS. | IGEN INC (US) | 1988-05-04 | — | — | EP | disclosed |
| WO-1987006706-A1 | ELECTROCHEMILUMINESCENT ASSAYS | IGEN, INC. (US) | 1987-11-05 | — | — | WO | disclosed |
| EP-0061731-B1 | NOVEL PHOSPHORIC ESTER AND A METHOD FOR QUANTITATIVE ANALYSIS OF AN ALKALINE PHOSPHATASE USING THE SAME AS A SUBSTRATE | Fuji Photo Film Co., Ltd. (JP) | 1986-10-29 | — | — | EP | disclosed |
| US-4610960-A | Monoclonal antibody to thrombospondin and method for assaying for and isolating thrombospondin | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1986-09-09 | — | — | US | disclosed |
| EP-0061731-A2 | Novel phosphoric ester and a method for quantitative analysis of an alkaline phosphatase using the same as a substrate | Fuji Photo Film Co., Ltd. (JP) | 1982-10-06 | — | — | EP | disclosed |