Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MYC | P01106 | 2/20 | 0.36 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4758043 | 0.82 | CRHBP (0.40) | SMN1; SMN2NOTUMLMNAMEN1POLB | |
| SCHEMBL3393583 | 0.77 | TSHR (0.40) | SMN1; SMN2TSHRNOTUMLMNAMEN1 | |
| SCHEMBL3394019 | 0.75 | CCR2 (0.43) | TSHRNOTUMSLC6A3SRD5A2 | |
| SCHEMBL4758286 | 0.70 | TSHR (0.36) | SMN1; SMN2TSHRCASP1HCAR2NOTUM | |
| SCHEMBL3391587 | 0.69 | KDM4E (0.44) | SMN1; SMN2MEN1KMT2ASLC6A3ALDH1A1 | |
| SCHEMBL3394045 | 0.68 | MEN1 (0.34) | TSHRCASP1LMNAMEN1POLB | |
| SCHEMBL4939279 | 0.66 | PTGDR2 (0.37) | SMN1; SMN2TSHRCASP1HCAR2NOTUM | |
| SCHEMBL4756140 | 0.63 | CRHBP (0.35) | SMN1; SMN2LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL11487945 | 0.63 | SLC6A3 (0.37) | SMN1; SMN2CASP1HCAR2LMNAPOLB | |
| SCHEMBL5533178 | 0.62 | HCAR2 (0.39) | SMN1; SMN2TSHRCASP1HCAR2NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008006070-A2 | COMPOUNDS AND COMBINATIONS THEREOF FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF USE THEREOF | ROSKAMP RESEARCH LLC (US) | 2008-01-10 | — | — | WO | disclosed |
| EP-1858325-A2 | COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF IDENTIFYING THE COMPOUNDS | Roskamp Research LLC (US) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006074419-A2 | COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF IDENTIFYING THE COMPOUNDS | ROSKAMP RESEARCH LLC (US) | 2006-07-13 | — | — | WO | disclosed |