SCHEMBL475861

SCHEMBL475861

CC(=O)O[Si](C(C)C)(C(C)C)C(C)C

nearest known ligand 0.41

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.41
ALDH1A1 P00352 2/20 0.35
CHRM2 P08172 1/20 0.31
CHRM4 P08173 1/20 0.31
CHRM1 P11229 1/20 0.31
TBXA2R P21731 1/20 0.31
GALR3 O60755 1/20 0.30
MAPT P10636 1/20 0.30
BLM P54132 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22557953 0.81 TSHR (0.32) TSHR
SCHEMBL22557955 0.77 TP53 (0.33)
SCHEMBL509444 0.77 TSHR (0.41) TSHRALDH1A1CHRM2CHRM4CHRM1
SCHEMBL707326 0.77 TSHR (0.41) TSHRALDH1A1CHRM2CHRM4CHRM1
SCHEMBL7143131 0.76 TSHR (0.46) TSHRALDH1A1
SCHEMBL1963691 0.76 TSHR (0.46) TSHRALDH1A1
SCHEMBL7114518 0.75
SCHEMBL475860 0.74
SCHEMBL3237373 0.74 LMNA (0.33) TSHRCHRM2CHRM4CHRM1MAPT
SCHEMBL476054 0.74 TSHR (0.39) TSHRALDH1A1CHRM2CHRM4CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 90 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8148446-B2 Silyl esters, their use in binder systems and paint compositions and a process of production thereof SIGMAKALON B.V. (NL) 2012-04-03 US claimed
US-20100249298-A1 Silyl esters, their use in binder systems and paint compositions and a process of production thereof GILLARD MICHEL 2010-09-30 US claimed
US-20070161722-A1 Silyl Esters, Their Use in Binder Systems and Paint Compositions and a Process for Production Thereof SIGMA COATINGS B.V. (NL) 2007-07-12 US claimed
EP-1620514-A2 SILYL ESTERS, THEIR USE IN BINDER SYSTEMS AND PAINT COMPOSITIONS AND A PROCESS OF PRODUCTION THEREOF SigmaKalon B.V. (NL) 2006-02-01 EP claimed
EP-1606329-A1 A PROCESS FOR THE PRODUCTION OF ACID GROUP CONTAINING POLYMER RESIN SigmaKalon B.V. (NL) 2005-12-21 EP claimed
EP-1606338-A1 A PROCESS FOR THE PROTECTION OF ACID GROUPS IN POLYMERS SigmaKalon B.V. (NL) 2005-12-21 EP claimed
US-20050222446-A1 Process for the production of hydrocarbyl silyl carboxylate compounds SIGMA COATINGS B.V. (NL) 2005-10-06 US claimed
WO-2004099326-A2 SILYL ESTERS, THEIR USE IN BINDER SYSTEMS AND PAINT COMPOSITIONS AND A PROCESS OF PRODUCTION THEREOF SIGMAKALON B.V. (NL) 2004-11-18 WO claimed
EP-1475415-A1 Silyl esters, their use in binder systems and paint compositions and a process of production thereof SigmaKalon Services B.V. (NL) 2004-11-10 EP claimed
WO-2004085518-A1 A PROCESS FOR THE PROTECTION OF ACID GROUPS IN POLYMERS SIGMAKALON B.V. (NL) 2004-10-07 WO claimed
WO-2004085502-A1 A PROCESS FOR THE PRODUCTION OF ACID GROUP CONTAINING POLYMER RESIN SIGMAKALON B.V. (NL) 2004-10-07 WO claimed
EP-1462472-A1 A process for the protection of acid groups in polymers Sigma Kalon Services B.V. (NL) 2004-09-29 EP claimed
EP-1462467-A1 A process for the production of silyl group containing polymer resin Sigma Kalon Services B.V. (NL) 2004-09-29 EP claimed
US-20260078130-A1 NAMPT MODULATORS, PREPARATIONS, AND USES THEREOF SIRONAX LTD (KY) 2026-03-19 US disclosed
EP-4590674-A1 NAMPT MODULATORS, PREPARATIONS, AND USES THEREOF Sironax Ltd (KY) 2025-07-30 EP disclosed
EP-4126335-A1 ANTIFOULING COATING COMPOSITION Jotun A/S (NO) 2023-02-08 EP disclosed
EP-1378514-A1 Process for the preparation of acyloxysilanes SigmaKalon Group B.V. (NL) 2004-01-07 EP disclosed
EP-1359166-A1 OLEFIN POLYMERIZATION CATALYST, CATALYST COMPONENT FOR OLEFIN POLYMERIZATION, METHOD OF STORING THESE, AND PROCESS FOR PRODUCING OLEFIN POLYMER Sunallomer Ltd (JP) 2003-11-05 EP disclosed
WO-2003080747-A1 FILM-FORMING POLYMER AND ANTIFOULING PAINT JOTUN AS (NO) 2003-10-02 WO disclosed
WO-2003027124-A1 PROCESS FOR THE PREPARATION OF ORGANOSILYLATED CARBOXYLATE MONOMERS, AND THEIR USE IN ANTIFOULING COATINGS SIGMA COATINGS B.V. (NL) 2003-04-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260078130-A1 NAMPT MODULATORS, PREPARATIONS, AND USES THEREOF NAMPT, NNMT, SARM1 TSHR 363/4885ALDH1A1 2719/4885CHRM2 564/4885
US-20100249298-A1 Silyl esters, their use in binder systems and paint compositions and a process of production thereof LCT, PCMT1, TST TSHR 4814/4885ALDH1A1 2426/4885CHRM2 3289/4885
US-20050222446-A1 Process for the production of hydrocarbyl silyl carboxylate compounds FTO, SUCLG2, ALKBH3 TSHR 4796/4885ALDH1A1 212/4885CHRM2 1077/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.