Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4773742 | 0.85 | GPR35 (0.60) | GPR35ALDH1A1LMNATDP1MAOA | |
| SCHEMBL11540656 | 0.80 | MAOA (0.57) | GPR35ALDH1A1TDP1MAOAMAPT | |
| SCHEMBL4778868 | 0.79 | GPR35 (0.63) | GPR35ALDH1A1LMNATDP1MAOA | |
| SCHEMBL4761517 | 0.75 | GPR35 (0.59) | GPR35ALDH1A1LMNATDP1MAOA | |
| SCHEMBL4250005 | 0.75 | GPR35 (1.00) | GPR35ALDH1A1LMNATDP1KDM4E | |
| SCHEMBL27485531 | 0.75 | GPR35 (0.59) | GPR35ALDH1A1LMNATDP1MAOA | |
| SCHEMBL4773013 | 0.75 | KDM4E (0.42) | GPR35ALDH1A1TDP1MAPTKDM4E | |
| SCHEMBL7628829 | 0.74 | GPR35 (0.78) | GPR35ALDH1A1LMNATDP1MAOA | |
| SCHEMBL27561844 | 0.74 | GPR35 (0.51) | GPR35ALDH1A1LMNATDP1MAOA | |
| SCHEMBL3085553 | 0.74 | MAPT (0.62) | GPR35ALDH1A1LMNATDP1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1897873-A1 | A process for the preparation of nitrile compounds used as intermediates in the synthesis of cysteinyl leukotrienes antagonists | Dipharma Francis S.r.l. (IT) | 2008-03-12 | — | — | EP | claimed |
| US-20080039640-A1 | PROCESS FOR THE PREPARATION OF NITRILE COMPOUNDS | DIPHARMA FRANCIS S.R.L. (IT) | 2008-02-14 | — | — | US | claimed |
| EP-1897873-A1 | A process for the preparation of nitrile compounds used as intermediates in the synthesis of cysteinyl leukotrienes antagonists | Dipharma Francis S.r.l. (IT) | 2008-03-12 | — | — | EP | disclosed |
| US-20080039640-A1 | PROCESS FOR THE PREPARATION OF NITRILE COMPOUNDS | DIPHARMA FRANCIS S.R.L. (IT) | 2008-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039640-A1 | PROCESS FOR THE PREPARATION OF NITRILE COMPOUNDS | NOS1, REN, NOS2 | GPR35 3732/4885ALDH1A1 811/4885LMNA 2213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.