SCHEMBL4778723

SCHEMBL4778723

CCCC[Sn](CCCC)(CCCC)c1[nH]c2cc(OC)cc(CC)c2c1C#N

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.33
HPGD P15428 6/20 0.33
KDM4E B2RXH2 5/20 0.33
GAA P10253 4/20 0.33
GLA P06280 3/20 0.33
HTT P42858 3/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
MAPT P10636 2/20 0.33
TDP1 Q9NUW8 2/20 0.33
HSD17B10 Q99714 4/20 0.32
CYP1A2 P05177 2/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2C19 P33261 1/20 0.32
GPR84 Q9NQS5 1/20 0.32
LMNA P02545 1/20 0.31
RAB9A P51151 1/20 0.31
MEN1 O00255 3/20 0.31
KMT2A Q03164 3/20 0.31
CASP1 P29466 1/20 0.31
CASP7 P55210 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4779864 0.70 NOX1 (0.41) ALDH1A1HPGDKDM4EMAPTMEN1
SCHEMBL4879715 0.70 PIM1 (0.44) ALDH1A1HPGDKDM4EGAAGLA
SCHEMBL4774067 0.68 RXRA (0.44) ALDH1A1HPGDKDM4EGAAGLA
SCHEMBL21710541 0.61 ALOX5 (0.48) ALDH1A1TDP1HSD17B10CYP1A2CYP3A4
SCHEMBL5953070 0.61 ALDH1A1 (0.44) ALDH1A1CYP1A2CYP3A4CYP2C19GPR84
SCHEMBL981643 0.58 KDM4E (0.44) ALDH1A1KDM4EHTTSMN1; SMN2MAPT
SCHEMBL1255316 0.57 ACHE (0.41) ALDH1A1GAAMAPTTDP1CYP3A4
SCHEMBL21780744 0.56 NPC1 (0.47) ALDH1A1KDM4EGAAGLASMN1; SMN2
SCHEMBL13652097 0.56 NOS2 (0.51) ALDH1A1HPGDKDM4EGAAGLA
SCHEMBL31200955 0.56 TSHR (0.40) ALDH1A1HPGDGAASMN1; SMN2HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1979315-A2 METHODS FOR TREATING HEPATITIS C PTC Therapeutics, Inc. (US) 2008-10-15 EP disclosed
WO-2007084435-A2 METHODS FOR TREATING HEPATITIS C PTC THERAPEUTICS, INC. (US) 2007-07-26 WO disclosed