Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.38 |
| ▸ | SOAT1 | P35610 | 4/20 | 0.34 |
| ▸ | ELANE | P08246 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | SOAT2 | O75908 | 2/20 | 0.33 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | STAT1 | P42224 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7572055 | 0.70 | GPR3 (0.35) | ALDH1A1NPC1PTPN1 | |
| SCHEMBL16500362 | 0.67 | EPHX1 (0.50) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL8592722 | 0.67 | CCKBR (0.49) | ALDH1A1 | |
| SCHEMBL10372389 | 0.65 | L3MBTL1 (0.40) | MAPT | |
| SCHEMBL8897910 | 0.64 | KCNH3 (0.37) | KCNH3SOAT1ELANESIGMAR1S1PR2 | |
| SCHEMBL10373566 | 0.64 | CYP1A2 (0.40) | SMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL1926387 | 0.62 | L3MBTL1 (0.48) | KCNH3SOAT1SIGMAR1S1PR2LMNA | |
| SCHEMBL96273 | 0.61 | ALDH1A1 (0.70) | KCNH3SOAT1SIGMAR1S1PR2LMNA | |
| SCHEMBL634078 | 0.60 | ALDH1A1 (0.67) | KCNH3SOAT1ELANESIGMAR1S1PR2 | |
| SCHEMBL10490557 | 0.60 | ALDH1A1 (0.67) | KCNH3SOAT1ELANESIGMAR1S1PR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |
| EP-1326849-B1 | BENZODIAZEPINE DERIVATIVES AS INHIBITORS OF GAMMA SECRETASE | MERCK SHARP & DOHME (GB) | 2008-07-16 | — | — | EP | disclosed |
| US-6995155-B2 | Benzodiazepine derivatives as inhibitors of gamma secretase | MERCK SHARP & DOHME LIMITED (GB) | 2006-02-07 | — | — | US | disclosed |
| US-20040024203-A1 | Benzodiazepine derivatives as inhibitors of gamma secretase | MERCK SHARP & DOHME LTD. (GB) | 2004-02-05 | — | — | US | disclosed |
| EP-1326849-A1 | BENZODIAZEPINE DERIVATIVES AS INHIBITORS OF GAMMA SECRETASE | Merck Sharp & Dohme Limited (GB) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002030912-A1 | BENZODIAZEPINE DERIVATIVES AS INHIBITORS OF GAMMA SECRETASE | MERCK SHARP & DOHME LIMITED (GB) | 2002-04-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040024203-A1 | Benzodiazepine derivatives as inhibitors of gamma secretase | BACE1, BACE2, PSEN1 | KCNH3 1341/4885SOAT1 2390/4885ELANE 2352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.