Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 4/20 | 0.35 |
| ▸ | DRD3 | P35462 | 4/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 5/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788517 | 0.69 | L3MBTL1 (0.43) | HRH4LMNAPOLBKMT2AMAPT | |
| SCHEMBL4750457 | 0.65 | HTR2C (0.41) | HTR6SMN1; SMN2KDM4E | |
| SCHEMBL8160398 | 0.65 | SIGMAR1 (0.36) | MC4RDRD2DRD3DRD4ADRA2C | |
| SCHEMBL4749790 | 0.64 | HRH1 (0.41) | SMN1; SMN2LMNAKMT2AMAPTKDM4E | |
| SCHEMBL6819394 | 0.64 | DRD2 (0.43) | DRD2DRD3KMT2ASIGMAR1TMEM97 | |
| Lithium Ion SCHEMBL4750393 | 0.63 | SIGMAR1 (0.39) | DRD2ADRA2CLMNASIGMAR1HTR1A | |
| SCHEMBL6820056 | 0.62 | ADRA1A (0.39) | DRD2DRD3ADRA2CHTR6POLB | |
| SCHEMBL6820067 | 0.62 | ADRA1A (0.39) | DRD2DRD3ADRA2CHTR6POLB | |
| SCHEMBL4747515 | 0.62 | ADRA2C (0.38) | DRD2DRD3DRD4ADRA2CHTR6 | |
| SCHEMBL4787846 | 0.62 | HRH1 (0.47) | DRD2DRD3DRD4SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130321-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR 5-HETEROCYCLYL-CHROMANE OR 8-HETEROCYCLYL-TETRAHYDRONAPHTALENE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |