Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
| ▸ | NPY2R | P49146 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | SCN1A | P35498 | 2/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.35 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4750457 | 0.91 | HTR2C (0.41) | HRH1KDM4ESMN1; SMN2NPY1RNPY2R | |
| SCHEMBL4750969 | 0.86 | HTR2C (0.38) | HRH1HTR2CHTR2BMEN1KMT2A | |
| SCHEMBL4787846 | 0.75 | HRH1 (0.47) | HRH1KDM4ESMN1; SMN2 | |
| SCHEMBL4788517 | 0.73 | L3MBTL1 (0.43) | KDM4EMAPTLMNAALDH1A1KDM1A | |
| SCHEMBL4788942 | 0.71 | GABRA1 (0.34) | KDM4EMAPTKDM1AMEN1KMT2A | |
| SCHEMBL4750047 | 0.69 | SMN1; SMN2 (0.39) | HRH1KDM4ESMN1; SMN2NPY1RNPY2R | |
| Lithium Ion SCHEMBL4750393 | 0.65 | SIGMAR1 (0.39) | LMNANPSR1KDM1A | |
| SCHEMBL4789083 | 0.64 | MC4R (0.35) | KDM4ESMN1; SMN2MAPTLMNAALDH1A1 | |
| SCHEMBL4747586 | 0.64 | NOS3 (0.40) | HTR2CHTR2B | |
| SCHEMBL4786874 | 0.63 | DRD2 (0.52) | KDM4ESMN1; SMN2NPY1RNPY2RKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |