Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | P2RX1 | P51575 | 4/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | TMPRSS4 | Q9NRS4 | 2/20 | 0.37 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | MLYCD | O95822 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3417238 | 0.87 | MEN1 (0.46) | HSP90AA1HSP90AB1P2RX1PIK3CAMEN1 | |
| SCHEMBL4116150 | 0.86 | MEN1 (0.45) | HSP90AA1HSP90AB1P2RX1PIK3CAMEN1 | |
| SCHEMBL4463291 | 0.82 | P2RX1 (0.39) | HSP90AA1HSP90AB1P2RX1PIK3CATMPRSS4 | |
| SCHEMBL10786186 | 0.74 | CES2 (0.50) | P2RX1PIK3CATMPRSS4P2RX4P2RX7 | |
| SCHEMBL5512932 | 0.69 | ALDH1A1 (0.48) | CRHBPCRHR2KIF11 | |
| Potassium Ion SCHEMBL4116152 | 0.68 | RORC (0.47) | P2RX1PIK3CATMPRSS4P2RX4P2RX7 | |
| SCHEMBL24450665 | 0.65 | MEN1 (0.47) | HSP90AA1HSP90AB1P2RX1PIK3CATMPRSS4 | |
| SCHEMBL8949391 | 0.65 | KDM4E (0.40) | HSP90AA1HSP90AB1P2RX1PIK3CATMPRSS4 | |
| Trifluoroacetic Acid SCHEMBL25310766 | 0.65 | HSP90AA1 (0.50) | HSP90AA1HSP90AB1P2RX1HDAC8MEN1 | |
| SCHEMBL13618923 | 0.65 | PTPN11 (0.45) | P2RX1PIK3CAPDK2PDK4PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004164-A1 | PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING DEGENERATIVE AND INFLAMMATORY DISEASES | Neurotech Co., Ltd. (KR) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007119973-A1 | PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING DEGENERATIVE AND INFLAMMATORY DISEASES | NEUROTECH CO., LTD. (KR) | 2007-10-25 | — | — | WO | disclosed |