Pyridine

Pyridine

SCHEMBL4807582

CC#N.CCN(CC)CC.O.c1ccncc1

nearest known ligand 0.41

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Pyridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.41
NAPRT Q6XQN6 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
CHRNB2 P17787 1/20 0.31
CHRNA4 P43681 1/20 0.31
MAPT P10636 1/20 0.30
CRHBP P24387 1/20 0.30
CRHR2 Q13324 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pyridine SCHEMBL3986375 0.91 TDP1 (0.50) TSHRNAPRTTDP1CHRNB2CHRNA4
Pyridine SCHEMBL290841 0.88 TDP1 (0.53) TSHRNAPRTTDP1CHRNB2CHRNA4
Pyridine SCHEMBL28136040 0.87 HTT (0.32) TSHRNAPRTTDP1
Pyridine SCHEMBL8356836 0.84 TDP1 (0.43) TSHRNAPRTTDP1CHRNB2CHRNA4
Pyridine SCHEMBL26930 0.83
Pyridine SCHEMBL16048785 0.83 TSHR (0.60) TSHRNAPRTTDP1
Pyridine SCHEMBL9655437 0.81 TSHR (0.45) TSHRNAPRTTDP1CHRNB2CHRNA4
Pyridine SCHEMBL6290122 0.80 TSHR (0.56) TSHRNAPRTTDP1
Pyridine SCHEMBL7695535 0.80 TSHR (0.56) TSHRNAPRTTDP1MAPT
Pyridine SCHEMBL28346173 0.80 TSHR (0.56) TSHRNAPRTTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230107647-A1 SINGLE MOLECULE PEPTIDE SEQUENCING BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2023-04-06 US disclosed
US-11162952-B2 Single molecule peptide sequencing BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2021-11-02 US disclosed
US-10545153-B2 Single molecule peptide sequencing BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2020-01-28 US disclosed
US-20170276686-A1 SINGLE MOLECULE PEPTIDE SEQUENCING BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2017-09-28 US disclosed
EP-2766389-B1 GENE CLUSTER FOR BIOSYNTHESIS OF GRISELIMYCIN AND METHYLGRISELIMYCIN SANOFI SA (FR) 2017-03-29 EP disclosed
US-9422566-B2 Gene cluster for biosynthesis of griselimycin and methylgriselimycin SANOFI (FR) 2016-08-23 US disclosed
US-20140295457-A1 GENE CLUSTER FOR BIOSYNTHESIS OF GRISELIMYCIN AND METHYLGRISELIMYCIN SANOFI (FR) 2014-10-02 US disclosed
EP-2586791-A1 Gene cluster for biosynthesis of griselimycin and methylgriselimycin SANOFI (FR) 2013-05-01 EP disclosed
US-7452701-B2 Methods for the preparation of β-amino acids WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2008-11-18 US disclosed
US-20080268510-A1 METHOD FOR PRODUCING L-BETA-LYSINE WISCONSIN ALUMNI RESEARCH FOUNDATION 2008-10-30 US disclosed
US-7354745-B2 Method for producing L-β-lysine WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2008-04-08 US disclosed
WO-2004021981-A2 METHODS FOR THE PREPARATION OF β-AMINO ACIDS WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2004-03-18 WO disclosed
US-20030113882-A1 Methods for the preparation of beta-amino acids WISCONSIN ALUMNI RESEARCH FOUNDATION 2003-06-19 US disclosed
US-20020173637-A1 Method for producing L-beta-lysine WISCONSIN ALUMNI RESEARCH FOUNDATION (WARF). 2002-11-21 US disclosed
US-6248874-B1 EXPRESSION VECTORS FOR THE GENERATION OF ENZYMATIC PROTEIN WISCONSIN ALUMNI RESEARCH FOUNDATION 2001-06-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230107647-A1 SINGLE MOLECULE PEPTIDE SEQUENCING QPCTL, ANPEP, VIP TSHR 3578/4885NAPRT 4566/4885TDP1 3386/4885
US-11162952-B2 Single molecule peptide sequencing MICA, ANPEP, VIP TSHR 4070/4885NAPRT 4286/4885TDP1 715/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.