Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 3/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | VEGFA | P15692 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | UBE2N | P61088 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3239791 | 0.79 | RAPGEF4 (0.50) | RAPGEF4CA1CA2L3MBTL1GAA | |
| SCHEMBL30892366 | 0.77 | L3MBTL1 (0.50) | RAPGEF4CA1CA2L3MBTL1GAA | |
| SCHEMBL3188642 | 0.77 | RAPGEF4 (0.61) | RAPGEF4CA1CA2L3MBTL1GAA | |
| SCHEMBL3834757 | 0.76 | RAPGEF4 (0.65) | RAPGEF4CA1CA2L3MBTL1GAA | |
| SCHEMBL16540512 | 0.76 | RAPGEF4 (0.56) | RAPGEF4CA1CA2L3MBTL1GAA | |
| SCHEMBL29179080 | 0.76 | L3MBTL1 (0.48) | RAPGEF4CA1CA2L3MBTL1GAA | |
| SCHEMBL10176180 | 0.75 | HTR6 (0.47) | RAPGEF4L3MBTL1TSHRCYP2C19POLB | |
| SCHEMBL8962760 | 0.74 | LMNA (0.44) | RAPGEF4CA1CA2L3MBTL1GAA | |
| SCHEMBL23699019 | 0.73 | RAPGEF4 (0.61) | RAPGEF4CA1CA2L3MBTL1GAA | |
| SCHEMBL5535689 | 0.73 | RAPGEF4 (0.61) | RAPGEF4CA1CA2L3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7446186-B2 | Pyrroles substituted by oligonucleotides | BIOMERIEUX (FR) | 2008-11-04 | — | — | US | disclosed |
| US-20060189555-A1 | Pyrroles substituted by oligonucleotides | APIBIO (FR) | 2006-08-24 | — | — | US | disclosed |
| EP-1578759-A1 | PYRROLES SUBSTITUTED BY OLIGONUCLEOTIDES | BIOMERIEUX SA (FR) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004060904-A1 | PYRROLES SUBSTITUTED BY OLIGONUCLEOTIDES | BIOMERIEUX SA (FR) | 2004-07-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060189555-A1 | Pyrroles substituted by oligonucleotides | POLR2E, NSUN3, RNGTT | RAPGEF4 4302/4885CA1 2900/4885CA2 3174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.