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SCHEMBL4839349

SCHEMBL4839349

CC(C)(C)OC(=O)CC(CCCSC(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)OC(C)(C)C

nearest known ligand 0.49

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ MMP1 P03956 10/20 0.49
▸ MMP3 P08254 9/20 0.49
▸ MMP9 P14780 2/20 0.49
▸ BIRC2 Q13490 1/20 0.48
▸ MAPT P10636 2/20 0.44
▸ TDP1 Q9NUW8 2/20 0.44
▸ POLB P06746 1/20 0.43
▸ MMP2 P08253 10/20 0.43
▸ MMP7 P09237 1/20 0.43
▸ MMP8 P22894 2/20 0.42
▸ ITGA4 P13612 1/20 0.42
▸ ITGB7 P26010 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6267060 0.93 MMP2 (0.51) MMP1MMP3MMP9BIRC2MMP2
SCHEMBL4839062 0.92 MMP3 (0.39) MMP1MMP3MMP9BIRC2MMP2
SCHEMBL4835726 0.80 KIF11 (0.42) —
SCHEMBL4839312 0.79 MEN1 (0.41) TDP1POLB
SCHEMBL4838555 0.79 CA2 (0.42) MMP1MMP3MMP2
SCHEMBL6294116 0.77 MMP2 (0.62) MMP1MMP3BIRC2MMP2MMP7
SCHEMBL8469705 0.76 MMP2 (0.50) MMP1MMP3MMP9BIRC2MMP2
SCHEMBL8828135 0.75 MMP3 (0.72) MMP1MMP3MMP9MMP2MMP7
SCHEMBL8828128 0.75 MMP1 (0.72) MMP1MMP3MMP9MMP2MMP7
SCHEMBL8055025 0.75 MMP2 (0.77) MMP1MMP3MMP9MMP2MMP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7365091-B2 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of PHEX ENOBIA PHARMA (CA) 2008-04-29 — — US disclosed
US-20060287280-A1 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of PHEX ENOBIA PHARMA (CA) 2006-12-21 — — US disclosed
US-7105539-B2 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex ENOBIA PHARMA (CA) 2006-09-12 — — US disclosed
US-20060135480-A1 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex ENOBIA PHARMA (CA) 2006-06-22 — — US disclosed
US-20040186301-A1 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex BIOMEP INC. 2004-09-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060287280-A1 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of PHEX GLS, SUCNR1, PGD MMP1 3031/4885MMP3 2546/4885MMP9 3110/4885
US-20040186301-A1 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex GLS, SUCNR1, PGD MMP1 2905/4885MMP3 2631/4885MMP9 3196/4885
US-20060135480-A1 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex GLS, SUCNR1, GCDH MMP1 3004/4885MMP3 2752/4885MMP9 3234/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.