Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | TAS1R3 | Q7RTX0 | 6/20 | 0.48 |
| ▸ | TAS1R1 | Q7RTX1 | 6/20 | 0.48 |
| ▸ | TAS1R2 | Q8TE23 | 6/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.42 |
| ▸ | CFD | P00746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4866589 | 0.85 | TAS1R3 (0.46) | ALDH1A1TAS1R3TAS1R1TAS1R2POLB | |
| SCHEMBL16709609 | 0.82 | TAS1R3 (0.47) | ALDH1A1TAS1R3TAS1R1TAS1R2POLB | |
| SCHEMBL4019187 | 0.80 | EPHX2 (0.46) | ALDH1A1TAS1R3TAS1R1TAS1R2POLB | |
| SCHEMBL30985347 | 0.78 | ALDH1A1 (0.83) | ALDH1A1TAS1R3TAS1R1TAS1R2POLB | |
| SCHEMBL4866618 | 0.78 | ALDH1A1 (0.83) | ALDH1A1TAS1R3TAS1R1TAS1R2POLB | |
| SCHEMBL4858887 | 0.78 | ALDH1A1 (0.83) | ALDH1A1TAS1R3TAS1R1TAS1R2POLB | |
| SCHEMBL14698658 | 0.78 | ALDH1A1 (0.83) | ALDH1A1TAS1R3TAS1R1TAS1R2POLB | |
| SCHEMBL23871584 | 0.76 | DRD2 (0.45) | TAS1R3TAS1R1TAS1R2PDE10AKMT2A | |
| SCHEMBL6634971 | 0.76 | ALDH1A1 (0.49) | ALDH1A1TAS1R3TAS1R1TAS1R2PDE10A | |
| SCHEMBL11775638 | 0.74 | TAS1R3 (0.57) | ALDH1A1TAS1R3TAS1R1TAS1R2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7407960-B2 | Substituted heterocyclic compounds | CV THERAPEUTICS, INC. (US) | 2008-08-05 | — | — | US | disclosed |
| EP-1806346-A1 | Substituted piperazine compounds and their use as fatty acid oxidation inhibitors | CV THERAPEUTICS, INC. (US) | 2007-07-11 | — | — | EP | disclosed |
| US-20070004751-A1 | Substituted heterocyclic compounds | ELZEIN ELFATIH | 2007-01-04 | — | — | US | disclosed |
| US-7125876-B2 | Substituted heterocyclic compounds | CV THERAPEUTICS, INC. (US) | 2006-10-24 | — | — | US | disclosed |
| US-20040152890-A1 | Substituted heterocyclic compounds | CV THERAPEUTICS, INC. | 2004-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040152890-A1 | Substituted heterocyclic compounds | KCNH1, SDHA, COQ8A | ALDH1A1 245/4885TAS1R3 4101/4885TAS1R1 4097/4885 |
| US-20070004751-A1 | Substituted heterocyclic compounds | KCNH1, SDHA, COQ8A | ALDH1A1 281/4885TAS1R3 4354/4885TAS1R1 4291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.