Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.58 |
| ▸ | DHODH | Q02127 | 1/20 | 0.50 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14916087 | 0.84 | AKR1C3 (0.49) | AKR1C3DHODHTRPM8KDM4EALDH1A1 | |
| SCHEMBL675699 | 0.84 | KDM4E (0.50) | AKR1C3KDM4EALDH1A1TSHRMEN1 | |
| SCHEMBL11044017 | 0.82 | AKR1C3 (0.58) | AKR1C3DHODHTRPM8KDM4EALDH1A1 | |
| SCHEMBL11044018 | 0.82 | AKR1C3 (0.58) | AKR1C3DHODHTRPM8KDM4EALDH1A1 | |
| SCHEMBL12848233 | 0.80 | TRPM8 (0.42) | AKR1C3DHODHTRPM8KDM4EALDH1A1 | |
| SCHEMBL18422153 | 0.79 | AKR1C3 (0.48) | AKR1C3DHODHTRPM8KDM4EALDH1A1 | |
| SCHEMBL11407221 | 0.77 | AKR1C3 (0.67) | AKR1C3DHODHTRPM8ALDH1A1TSHR | |
| SCHEMBL6064618 | 0.77 | AKR1C3 (0.67) | AKR1C3DHODHTRPM8ALDH1A1TSHR | |
| SCHEMBL351852 | 0.77 | AKR1C3 (0.67) | AKR1C3DHODHTRPM8ALDH1A1TSHR | |
| SCHEMBL778665 | 0.77 | KDM4E (0.48) | AKR1C3KDM4EALDH1A1TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102068420-B | Application of 2',4'-dihydroxy-6'-methoxyl-3',5'-dimethyl chalcone in preparation of medicaments for treating liver diseases | UNIV EAST CHINA SCIENCE & TECH | 2012-07-04 | — | — | CN | claimed |
| CN-102068420-A | Application of 2',4'-dihydroxy-6'-methoxyl-3',5'-dimethyl chalcone in preparation of medicaments for treating liver diseases | UNIV EAST CHINA SCIENCE & TECH | 2011-05-25 | — | — | CN | claimed |
| CN-101716166-A | Applications of 2', 4'-dihydroxyl-6'-methoxyl-3', 5'-dimethyl chalcone | UNIV EAST CHINA SCIENCE & TECH | 2010-06-02 | — | — | CN | claimed |
| WO-2023177191-A1 | COMPOSITION FOR PREVENTING OR TREATING FIBROTIC DISEASES, COMPRISING DIMETHYLCHALCONE DERIVATIVE AS ACTIVE INGREDIENT | 서울대학교 산학협력단 | 2023-09-21 | — | — | WO | disclosed |
| WO-2023177191-A1 | COMPOSITION FOR PREVENTING OR TREATING FIBROTIC DISEASES, COMPRISING DIMETHYLCHALCONE DERIVATIVE AS ACTIVE INGREDIENT | 서울대학교 산학협력단 | 2023-09-21 | — | — | WO | disclosed |
| WO-2023177194-A1 | NOVEL DIMETHYLCHALCONE DERIVATIVES | 중앙대학교 산학협력단 | 2023-09-21 | — | — | WO | disclosed |
| US-20230248665-A1 | COMPOSITION COMPRISING DIMETHYLCHALCONE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE | SEOUL NATIONAL UNIVERSITY R & DB FOUNDATION (KR) | 2023-08-10 | — | — | US | disclosed |
| US-20230248665-A1 | COMPOSITION COMPRISING DIMETHYLCHALCONE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE | SEOUL NATIONAL UNIVERSITY R & DB FOUNDATION (KR) | 2023-08-10 | — | — | US | disclosed |
| WO-2022060169-A4 | COMPOSITION COMPRISING DIMETHYLCHALCONE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE | 서울대학교 산학협력단 | 2022-05-12 | — | — | WO | disclosed |
| US-9744164-B2 | Neuroprotective polyphenol analogs | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2017-08-29 | — | — | US | disclosed |
| CN-106176698-A | Flos Cleistocalycis Operculati extract and preparation method thereof, application | 江苏康缘药业股份有限公司 | 2016-12-07 | — | — | CN | disclosed |
| CN-102068420-B | Application of 2',4'-dihydroxy-6'-methoxyl-3',5'-dimethyl chalcone in preparation of medicaments for treating liver diseases | UNIV EAST CHINA SCIENCE & TECH | 2012-07-04 | — | — | CN | disclosed |
| CN-101048651-B | Multifunctional reference system for use in analyte detection by fluorescence | HOFFMANN LA ROCHE | 2011-09-14 | — | — | CN | disclosed |
| CN-102068420-A | Application of 2',4'-dihydroxy-6'-methoxyl-3',5'-dimethyl chalcone in preparation of medicaments for treating liver diseases | UNIV EAST CHINA SCIENCE & TECH | 2011-05-25 | — | — | CN | disclosed |
| CN-101259118-B | Application of 2',4'-dihydroxy-6'-methoxy-3',5'-dimethyl chalcone as PPAR gamma agonist | GUANGZHOU INST BIOMED & HEALTH | 2010-06-16 | — | — | CN | disclosed |
| CN-101716166-A | Applications of 2', 4'-dihydroxyl-6'-methoxyl-3', 5'-dimethyl chalcone | UNIV EAST CHINA SCIENCE & TECH | 2010-06-02 | — | — | CN | disclosed |
| US-7432303-B2 | Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states | Bowen, J. Phillip (US) | 2008-10-07 | — | — | US | disclosed |
| CN-101259118-A | Application of 2',4'-dihydroxy-6'-methoxy-3',5'-dimethyl chalcone as PPAR gamma agonist | GUANGZHOU INST BIOMED & HEALTH (CN) | 2008-09-10 | — | — | CN | disclosed |
| CN-101048651-A | Multifunctional reference system for use in analyte detection by fluorescence | HOFFMANN LA ROCHE (CH) | 2007-10-03 | — | — | CN | disclosed |
| US-20050148599-A1 | Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | 2005-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230248665-A1 | COMPOSITION COMPRISING DIMETHYLCHALCONE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE | LIPC, PC, CYP27A1 | AKR1C3 450/4885DHODH 774/4885TRPM8 4474/4885 |
| US-20050148599-A1 | Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states | FLT1, VEGFA, FLT4 | AKR1C3 204/4885DHODH 369/4885TRPM8 3758/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.