Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9192740 | 0.97 | TSHR (0.46) | TSHRPTPN1CA1CA2CA9 | |
| Potassium Ion SCHEMBL343519 | 0.97 | TSHR (0.46) | TSHRPTPN1CA1CA2CA9 | |
| SCHEMBL9717029 | 0.80 | PTPN1 (0.51) | TSHRPTPN1CA1CA2CA9 | |
| SCHEMBL11217534 | 0.80 | PTPN1 (0.51) | TSHRPTPN1CA1CA2CA9 | |
| SCHEMBL11213067 | 0.80 | PTPN1 (0.51) | TSHRPTPN1CA1CA2CA9 | |
| SCHEMBL200212 | 0.77 | TSHR (0.59) | TSHRPTPN1CA1CA2CA9 | |
| SCHEMBL343520 | 0.76 | TSHR (0.57) | TSHRPTPN1CA1CA2CA9 | |
| SCHEMBL8880203 | 0.75 | ALDH1A1 (0.44) | ALDH1A1KDM4EHPGD | |
| SCHEMBL22265949 | 0.75 | PLA2G2A (0.49) | TSHRPTPN1CA1CA2CA9 | |
| SCHEMBL23003 | 0.72 | TSHR (0.79) | TSHRPTPN1CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-61047292-A | — | — | None | — | — | JP | disclosed |
| EP-1940629-B1 | IMAGE RECORDING MEDIA AND IMAGE LAYERS | HEWLETT PACKARD DEVELOPMENT CO (US) | 2013-09-25 | — | — | EP | disclosed |
| US-7314704-B2 | Image recording media and image layers | HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (US) | 2008-01-01 | — | — | US | disclosed |
| US-4630080-A | CONTAINING CALCIUM MONOBENZY PHTHALATE AS STABILIZER, AND A DIPHENYLSULFONE AS DEVELOPER FOR COLORLESS DYE | JUJO PAPER CO., LTD. (JP) | 1986-12-16 | — | — | US | disclosed |
| JP-S6147292-A | THERMAL RECORDING PAPER | JUJO PAPER CO LTD | 1986-03-07 | — | — | JP | disclosed |