Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Methylparaben. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 known ✓ | P00915 | 6/20 | 0.61 |
| ▸ | CA2 known ✓ | P00918 | 6/20 | 0.61 |
| ▸ | CA12 known ✓ | O43570 | 4/20 | 0.61 |
| ▸ | XDH known ✓ | P47989 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 4/20 | 0.61 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.61 |
| ▸ | CA7 | P43166 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylparaben SCHEMBL2810863 | 0.95 | CA1 (0.61) | CA1CA2CA12CA9CA14 | |
| Methylparaben SCHEMBL475868 | 0.95 | CA1 (0.61) | CA1CA2CA12CA9CA14 | |
| Methylparaben SCHEMBL5899662 | 0.86 | TSHR (0.63) | CA1CA2CA12CA9CA14 | |
| SCHEMBL28993944 | 0.85 | CA1 (0.80) | CA1CA2CA12CA9CA14 | |
| SCHEMBL23600 | 0.85 | CA1 (0.80) | CA1CA2CA12CA9CA14 | |
| Propylparaben SCHEMBL7607113 | 0.84 | ALDH1A1 (0.60) | TDP1TSHRMAPTALDH1A1MEN1 | |
| Methylparaben SCHEMBL27781967 | 0.83 | CA1 (0.69) | CA1CA2CA12CA9CA14 | |
| SCHEMBL28704033 | 0.83 | CA1 (0.76) | CA1CA2CA12CA9CA14 | |
| Water SCHEMBL22720573 | 0.83 | CA1 (0.76) | CA1CA2CA12CA9CA14 | |
| SCHEMBL28993277 | 0.83 | CA1 (0.76) | CA1CA2CA12CA9CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4754 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4743053-A1 | ANTIMICROBIAL SYNERGIES | Symrise AG (DE) | 2026-05-20 | — | — | EP | claimed |
| WO-2026099342-A1 | ORAL CARE COMPOSITION FOR USE IN THE TREATMENT OF DRY MOUTH | ORAL CARE SOLUTIONS GMBH (CH) | 2026-05-15 | — | — | WO | claimed |
| EP-4740931-A1 | ORAL CARE COMPOSITION FOR USE IN THE TREATMENT OF DRY MOUTH | Oral Care Solutions GmbH (CH) | 2026-05-13 | — | — | EP | claimed |
| US-20260124120-A1 | STABILIZED AQUEOUS COMPOSITIONS CONTAINING HYDROXYAPTITE AND FREE IONS FOR IN VIVO REMINERALIZATION OF CALCIFIED TISSUE & THEIR METHODS OF USE | INTER MED INC (US) | 2026-05-07 | — | — | US | claimed |
| WO-2026090627-A1 | STABLE PITOLISANT LIQUID FORMULATIONS AND METHOD OF ITS USE | PATEL SANDIPKUMAR (US) | 2026-04-30 | — | — | WO | claimed |
| US-12595237-B2 | Lamotrigine hydrate crystal form, preparation method therefor, and composition containing same | SHANGHAI AUCTA PHARMACEUTICALS CO., LTD. (CN) | 2026-04-07 | — | — | US | claimed |
| US-20260069570-A1 | STABLE PHARMACEUTICAL COMPOSITIONS OF EDARAVONE | SLAYBACK PHARMA LLC (US) | 2026-03-12 | — | — | US | claimed |
| EP-4554551-B1 | 3-HYDROXYPROPYLESTERS AS ANTIMICROBIAL AGENTS | SYMRISE AG (DE) | 2026-03-11 | — | — | EP | claimed |
| US-20260041094-A1 | Compositions Comprising an Antimicrobial Boosting Agent | SYMRISE AG (DE) | 2026-02-12 | — | — | US | claimed |
| US-12491178-B2 | Stable pharmaceutical compositions of edaravone | SLAYBACK PHARMA LLC (US) | 2025-12-09 | — | — | US | claimed |
| EP-1121105-A1 | PROPOFOL-BASED ANESTHETIC AND METHOD OF MAKING SAME | Phoenix Scientific, Inc. (US) | 2001-08-08 | — | — | EP | claimed |
| WO-2001032795-A1 | CYANOACRYLATE SOLUTIONS CONTAINING PRESERVATIVES | CLOSURE MEDICAL CORPORATION (US) | 2001-05-10 | — | — | WO | claimed |
| EP-1058535-A1 | DESENSITIZING DENTAL COMPOSITION | Italmed S.N.C. Di Galli G. E Pacini G. (IT) | 2000-12-13 | — | — | EP | claimed |
| WO-2000071175-A1 | OPHTHALMIC SOLUTIONS INCORPORATING AN ANTIMICROBIAL POLYPEPTIDE | LARGE SCALE BIOLOGY CORPORATION (US) | 2000-11-30 | — | — | WO | claimed |
| WO-2000021517-A1 | PROPOFOL-BASED ANESTHETIC AND METHOD OF MAKING SAME | PHOENIX SCIENTIFIC, INC. (US) | 2000-04-20 | — | — | WO | claimed |
| WO-2000008061-A1 | REACTION PRODUCTS OF HYALURONIC ACID AND NATURAL AMINO ACIDS AND THEIR USE IN COSMETIC AND PHARMACEUTICAL COMPOSITIONS | JASPER LTD. LIABILITY CO. (US) | 2000-02-17 | — | — | WO | claimed |
| EP-0971696-A1 | THIMEROSAL-FREE PRESERVATIVES FOR VACCINES | Merck & Co., Inc. (US) | 2000-01-19 | — | — | EP | claimed |
| WO-1999044570-A1 | DESENSITIZING DENTAL COMPOSITION | ITALMED S.N.C. DI GALLI G. E PACINI G. (IT) | 1999-09-10 | — | — | WO | claimed |
| WO-1998034594-A1 | THIMEROSAL-FREE PRESERVATIVES FOR VACCINES | MERCK & CO., INC. (US) | 1998-08-13 | — | — | WO | claimed |
| EP-0489217-A1 | Calcitonin compositions for intranasal administration | DR. A. TOSI FARMACEUTICI S.R.L. (IT) | 1992-06-10 | — | — | EP | claimed |