Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HSPA5 | P11021 | 4/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.44 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.44 |
| ▸ | HSPA2 | P54652 | 1/20 | 0.44 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10569530 | 0.89 | ALDH1A1 (0.55) | HPGDALDH1A1HSPA5CTSLRAB9A | |
| SCHEMBL1605401 | 0.89 | ALDH1A1 (0.55) | HPGDALDH1A1HSPA5CTSLRAB9A | |
| Methylamine SCHEMBL10771739 | 0.86 | HPGD (0.53) | HPGDALDH1A1HSPA5CTSLRAB9A | |
| SCHEMBL4874253 | 0.84 | HPGD (0.44) | HPGDALDH1A1HSPA5CTSLRAB9A | |
| SCHEMBL4384045 | 0.82 | CA2 (0.53) | HPGDALDH1A1HSPA5CTSLRAB9A | |
| SCHEMBL11399400 | 0.81 | HPGD (0.64) | HPGDALDH1A1RAB9AKDM4ECYP1A2 | |
| SCHEMBL2364398 | 0.80 | HPGD (0.54) | HPGDALDH1A1CTSLRAB9AKDM4E | |
| SCHEMBL9830868 | 0.79 | CA2 (0.53) | HPGDFOLH1HDAC1 | |
| SCHEMBL9705401 | 0.79 | RAB9A (0.54) | HPGDALDH1A1HSPA5CTSLRAB9A | |
| SCHEMBL11386076 | 0.79 | RAB9A (0.54) | HPGDALDH1A1HSPA5CTSLRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080262035-A1 | Amide Derivatives as Inhibitors of Histone Deacetylase | MERCK & CO., INC. | 2008-10-23 | — | — | US | disclosed |
| EP-1768956-A1 | AMIDE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. (IT) | 2007-04-04 | — | — | EP | disclosed |
| WO-2006005955-A1 | AMIDE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA (IT) | 2006-01-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080262035-A1 | Amide Derivatives as Inhibitors of Histone Deacetylase | HDAC1, HDAC5, HDAC11 | HPGD 445/4885ALDH1A1 235/4885HSPA5 1677/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.