SCHEMBL4886301

SCHEMBL4886301

Cc1cc(-c2cc(C)cc(C(C)(C)C)c2O)c(O)c(C(C)(C)C)c1

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 6/20 0.77
CA2 P00918 4/20 0.77
ALDH1A1 P00352 3/20 0.77
POLB P06746 1/20 0.77
TYR P14679 1/20 0.77
HSPA5 P11021 1/20 0.61
CYP2C9 P11712 4/20 0.59
CYP2C19 P33261 4/20 0.59
HIF1A Q16665 3/20 0.59
CA1 P00915 2/20 0.52
CYP2D6 P10635 1/20 0.52
HSD17B10 Q99714 1/20 0.52
CYP1A2 P05177 2/20 0.50
PTGS1 P23219 1/20 0.46
PTGS2 P35354 1/20 0.46
MAPT P10636 2/20 0.45
ALOX15 P16050 2/20 0.45
HPN P05981 1/20 0.45
SIRT5 Q9NXA8 1/20 0.45
KDM4E B2RXH2 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30782815 1.00 SMN1; SMN2 (0.77) SMN1; SMN2CA2ALDH1A1POLBTYR
SCHEMBL6866098 0.98 SMN1; SMN2 (0.74) SMN1; SMN2CA2ALDH1A1POLBTYR
SCHEMBL17126988 0.92 SMN1; SMN2 (0.65) SMN1; SMN2CA2ALDH1A1POLBTYR
Butylated Hydroxytoluene SCHEMBL453824 0.87 SMN1; SMN2 (1.00) SMN1; SMN2CA2ALDH1A1POLBTYR
Butylated Hydroxytoluene SCHEMBL3950 0.87 SMN1; SMN2 (1.00) SMN1; SMN2CA2ALDH1A1POLBTYR
SCHEMBL11233686 0.87 ALDH1A1 (0.59) SMN1; SMN2CA2ALDH1A1POLBTYR
SCHEMBL16281763 0.86 SMN1; SMN2 (0.63) SMN1; SMN2CA2ALDH1A1POLBTYR
Butylated Hydroxytoluene SCHEMBL9343307 0.85 SMN1; SMN2 (0.95) SMN1; SMN2CA2ALDH1A1POLBTYR
Butylated Hydroxytoluene SCHEMBL7075597 0.85 SMN1; SMN2 (0.95) SMN1; SMN2CA2ALDH1A1POLBTYR
Butylated Hydroxytoluene SCHEMBL20660368 0.85 SMN1; SMN2 (0.95) SMN1; SMN2CA2ALDH1A1POLBTYR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9517986-B2 Process for preparing 2,2′-biphenols using selenium dioxide EVONIK DEGUSSA GMBH (DE) 2016-12-13 US claimed
US-20150336865-A1 PROCESS FOR PREPARING 2,2'-BIPHENOLS USING SELENIUM DIOXIDE EVONIK DEGUSSA GMBH (DE) 2015-11-26 US claimed
EP-0764878-B1 Photothermographic elements comprising hydroxamic acid developers IMATION CORP (US) 2000-05-24 EP claimed
EP-0509740-B1 Heat-developable photosensitive material and image forming method making use of the heat-developable photosensitive material CANON KK (JP) 1996-06-26 EP claimed
EP-3717120-B1 HIGHLY ISOSELECTIVE CATALYST FOR ALKENE HYDROFORMYLATION EASTMAN CHEM CO (US) 2024-10-02 EP disclosed
EP-4393932-A1 DIPHOSPHONITES AND THEIR USE IN HYDROFORMYLATION Evonik Oxeno GmbH & Co. KG (DE) 2024-07-03 EP disclosed
US-20230357115-A1 PHOSPHOLANE-PHOSPHITE LIGANDS FOR ALKENE HYDROFORMYLATION CATALYSTS EASTMAN CHEMICAL COMPANY (US) 2023-11-09 US disclosed
EP-3717494-B1 HIGHLY ISOSELECTIVE CATALYST FOR ALKENE HYDROFORMYLATION EASTMAN CHEM CO (US) 2023-11-01 EP disclosed
US-20230265034-A1 OLEFIN HYDROFORMYLATION PROCESSES USING HYDROCARBON SOLVENTS AND FLUORINATED SOLVENTS IN THE PRESENCE OF PHOSPHOLANE-PHOSPHITE LIGANDS EASTMAN CHEMICAL COMPANY (US) 2023-08-24 US disclosed
EP-3717494-A1 HIGHLY ISOSELECTIVE CATALYST FOR ALKENE HYDROFORMYLATION Eastman Chemical Company (US) 2020-10-07 EP disclosed
US-10351583-B2 Highly isoselective catalyst for alkene hydroformylation EASTMAN CHEMICAL COMPANY (US) 2019-07-16 US disclosed
US-20190161508-A1 HIGHLY ISOSELECTIVE CATALYST FOR ALKENE HYDROFORMYLATION EASTMAN CHEMICAL COMPANY (US) 2019-05-30 US disclosed
US-5464738-A Heat-developable, black-and-white /photo/thermographic element including nonphotosensitive, reducible silver source, reducing agent for silver source, binder MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1995-11-07 US disclosed
US-5391801-A Used to form respective aldehyde by reacting olefinic compound with carbon monoxide and hydrogen in presence of group 8 metal catalyst MITSUBISHI KASEI CORPORATION (JP) 1995-02-21 US disclosed
US-5262295-A Biphenyldihydroxide reducing agent for silver halide emulsion layers CANON KABUSHIKI KAISHA (JP) 1993-11-16 US disclosed
US-5235113-A Reacting olefin with hydrogen and carbon monoxide in the presence of a group 8 metal catalyst and a phosphite compound MITSUBISHI KASEI CORPORATION (JP) 1993-08-10 US disclosed
EP-0518241-A2 Hydroformylation process and bisphosphite compound used therein Mitsubishi Chemical Corporation (JP) 1992-12-16 EP disclosed
EP-0509740-A1 Heat-developable photosensitive material and image forming method making use of the heat-developable photosensitive material CANON KABUSHIKI KAISHA (JP) 1992-10-21 EP disclosed
EP-0035965-B1 PROCESS FOR THE PREPARATION OF 2.2'-DIHYDROXYBIPHENYL COMPOUNDS CIBA-GEIGY AG (CH) 1983-05-18 EP disclosed
EP-0035965-A2 Process for the preparation of 2.2'-dihydroxybiphenyl compounds CIBA-GEIGY AG (CH) 1981-09-16 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230357115-A1 PHOSPHOLANE-PHOSPHITE LIGANDS FOR ALKENE HYDROFORMYLATION CATALYSTS PHOSPHO1, PFKFB4, PFKFB1 SMN1; SMN2 3868/4885CA2 3077/4885ALDH1A1 2851/4885
US-10351583-B2 Highly isoselective catalyst for alkene hydroformylation NUDT1, AHR, HMOX2 SMN1; SMN2 4401/4885CA2 3380/4885ALDH1A1 287/4885
US-20150336865-A1 PROCESS FOR PREPARING 2,2'-BIPHENOLS USING SELENIUM DIOXIDE SELENOI, PLK1, BPGM SMN1; SMN2 2205/4885CA2 431/4885ALDH1A1 2479/4885
US-20190161508-A1 HIGHLY ISOSELECTIVE CATALYST FOR ALKENE HYDROFORMYLATION NUDT1, AHR, HMOX2 SMN1; SMN2 4401/4885CA2 3380/4885ALDH1A1 287/4885
US-20230265034-A1 OLEFIN HYDROFORMYLATION PROCESSES USING HYDROCARBON SOLVENTS AND FLUORINATED SOLVENTS IN THE PRESENCE OF PHOSPHOLANE-PHOSPHITE LIGANDS PHOSPHO1, POF1B, OSBP SMN1; SMN2 3388/4885CA2 2414/4885ALDH1A1 3428/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.