Sugi Predict

Sugi Predict / Compounds / SCHEMBL489064

SCHEMBL489064

SCHEMBL489064

COC(=O)c1ccc(CBr)cc1F

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 3/20 0.45
▸ GAA P10253 3/20 0.45
▸ KDM4E B2RXH2 3/20 0.45
▸ MAPT P10636 2/20 0.45
▸ HPGD P15428 2/20 0.45
▸ HSD17B10 Q99714 2/20 0.45
▸ ALOX15 P16050 1/20 0.45
▸ TSHR P16473 1/20 0.45
▸ CYP4F2 P78329 2/20 0.44
▸ CYP4A11 Q02928 2/20 0.44
▸ CA12 O43570 1/20 0.42
▸ CA1 P00915 1/20 0.42
▸ CA2 P00918 1/20 0.42
▸ CA7 P43166 1/20 0.42
▸ PDK2 Q15119 1/20 0.42
▸ PDK4 Q16654 1/20 0.42
▸ CA9 Q16790 1/20 0.42
▸ CA14 Q9ULX7 1/20 0.42
▸ FFAR4 Q5NUL3 1/20 0.42
▸ HTT P42858 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27600987 0.87 FFAR4 (0.43) ALDH1A1GAAKDM4EMAPTHPGD
SCHEMBL2060890 0.87 ALDH1A1 (0.49) ALDH1A1GAAKDM4EMAPTHPGD
SCHEMBL30842613 0.87 ALDH1A1 (0.49) ALDH1A1GAAKDM4EMAPTHPGD
SCHEMBL8252765 0.86 GAA (0.47) ALDH1A1GAAKDM4EMAPTHPGD
SCHEMBL522653 0.85 CA12 (0.51) ALDH1A1GAAKDM4EMAPTHPGD
SCHEMBL1022658 0.84 ALDH1A1 (0.53) ALDH1A1GAAKDM4EMAPTHPGD
SCHEMBL29943277 0.84 ALDH1A1 (0.53) ALDH1A1GAAKDM4EMAPTHPGD
SCHEMBL28404736 0.84 CYP4F2 (0.42) CYP4F2CYP4A11MAOBEPHX2NR1H4
SCHEMBL22006228 0.83 CA12 (0.46) ALDH1A1GAAKDM4EMAPTHPGD
SCHEMBL507332 0.83 LOXL2 (0.54) ALDH1A1GAAKDM4EMAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 241 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12552804-B2 Tricyclic heterocycles as FGFR inhibitors INCYTE CORPORATION (US) 2026-02-17 — — US disclosed
EP-4007752-B1 KIF18A INHIBITORS AMGEN INC (US) 2025-09-24 — — EP disclosed
US-20250263402-A1 BENZIMIDAZOLONE GLP-1 RECEPTOR AGONIST AND USE THEREOF HANGZHOU ZHONGMEIHUADONG PHARMACEUTICAL CO., LTD. (CN) 2025-08-21 — — US disclosed
US-20250059183-A1 PYRIDINE[4,3-D]PYRIMIDINE COMPOUND AS TLR7/8 AGONIST SHANGHAI VISONPHARMA CO., LTD. (CN) 2025-02-20 — — US disclosed
US-12162864-B2 Condensed-cyclic compound TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2024-12-10 — — US disclosed
CN-118974051-A Pyrimidopyridazinones as Toll-like receptor agonists 上海维申医药有限公司 2024-11-15 — — CN disclosed
EP-4446323-A1 PYRIDINE[4,3-D]PYRIMIDINE COMPOUND AS TLR7/8 AGONIST Shanghai Visonpharma Co., Ltd. (CN) 2024-10-16 — — EP disclosed
US-20240287086-A1 TRICYCLIC HETEROCYCLES AS FGFR INHIBITORS INCYTE CORPORATION 2024-08-29 — — US disclosed
CN-118382625-A Pyridine [4,3-d ] pyrimidines as TLR7/8 agonists 上海维申医药有限公司 2024-07-23 — — CN disclosed
US-12024505-B2 Heterocyclic compounds useful as modulators of acetylcholine receptors TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2024-07-02 — — US disclosed
WO-2003016316-A1 DIAZACYCLOALKANES AS OXYTOCIN AGONISTS FERRING B.V. (NL) 2003-02-27 — — WO disclosed
WO-2003016316-A1 DIAZACYCLOALKANES AS OXYTOCIN AGONISTS FERRING B.V. (NL) 2003-02-27 — — WO disclosed
WO-2003000692-A2 OXYTOCIN AGONISTS FERRING BV (NL) 2003-01-03 — — WO disclosed
US-20020193377-A1 Quinazolines as MMP-13 inhibitors ANDRIANJARA CHARLES (FR) 2002-12-19 — — US disclosed
WO-2002064572-A1 QUINAZOLINES AS MMP-13 INHIBITORS WARNER-LAMBERT COMPANY LLC (US) 2002-08-22 — — WO disclosed
EP-1226122-A1 BICYCLIC VASOPRESSIN AGONISTS Ferring BV (NL) 2002-07-31 — — EP disclosed
WO-2002000626-A1 FUSED AZEPINE DERIVATIVES AND THEIR USE AS ANTIDIURETIC AGENTS FERRING B.V. (NL) 2002-01-03 — — WO disclosed
WO-2001029005-A1 BICYCLIC VASOPRESSIN AGONISTS FERRING BV (NL) 2001-04-26 — — WO disclosed
EP-0061907-B1 SECONDARY AMINES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE BEECHAM GROUP PLC (GB) 1984-08-01 — — EP disclosed
EP-0061907-A1 Secondary amines, their preparation, pharmaceutical compositions containing them and their use BEECHAM GROUP PLC (GB) 1982-10-06 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020193377-A1 Quinazolines as MMP-13 inhibitors MMP13, MMP9, MMP3 ALDH1A1 1357/4885GAA 2252/4885KDM4E 1784/4885
US-20250263402-A1 BENZIMIDAZOLONE GLP-1 RECEPTOR AGONIST AND USE THEREOF GLP1R, GIPR, GCGR ALDH1A1 2478/4885GAA 2290/4885KDM4E 3230/4885
US-12024505-B2 Heterocyclic compounds useful as modulators of acetylcholine receptors CHRM3, CHRNA1, CHRM5 ALDH1A1 1030/4885GAA 4183/4885KDM4E 2322/4885
US-20240287086-A1 TRICYCLIC HETEROCYCLES AS FGFR INHIBITORS FGFR3, FGFR1, FGFR2 ALDH1A1 879/4885GAA 426/4885KDM4E 911/4885
US-12162864-B2 Condensed-cyclic compound SLC10A2, VIP, AVPR2 ALDH1A1 1810/4885GAA 4009/4885KDM4E 2962/4885
US-12552804-B2 Tricyclic heterocycles as FGFR inhibitors FGFR3, FGFR1, FGFR2 ALDH1A1 478/4885GAA 2760/4885KDM4E 1539/4885
US-20250059183-A1 PYRIDINE[4,3-D]PYRIMIDINE COMPOUND AS TLR7/8 AGONIST TLR7, TLR8, TLR1 ALDH1A1 2284/4885GAA 3617/4885KDM4E 2160/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.