Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Betulinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALB | P02768 | 3/20 | 0.98 |
| ▸ | RORC | P51449 | 8/20 | 0.83 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.83 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.83 |
| ▸ | USP2 | O75604 | 1/20 | 0.83 |
| ▸ | LMNA | P02545 | 1/20 | 0.83 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.83 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.83 |
| ▸ | POLB | P06746 | 1/20 | 0.83 |
| ▸ | GLI1 | P08151 | 1/20 | 0.83 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.83 |
| ▸ | NT5E | P21589 | 1/20 | 0.83 |
| ▸ | DPP4 | P27487 | 1/20 | 0.83 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.83 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.83 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.80 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.80 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.80 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.80 |
| ▸ | CES2 | O00748 | 2/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12914993 | 0.92 | RORC (0.86) | ALBRORCPTPN1GPBAR1USP2 | |
| SCHEMBL25669596 | 0.92 | RORC (0.86) | ALBRORCPTPN1GPBAR1USP2 | |
| SCHEMBL17124251 | 0.92 | RORC (0.86) | ALBRORCPTPN1GPBAR1USP2 | |
| SCHEMBL13908798 | 0.92 | RORC (0.86) | ALBRORCPTPN1GPBAR1USP2 | |
| SCHEMBL12150548 | 0.92 | RORC (0.86) | ALBRORCPTPN1GPBAR1USP2 | |
| Betulinic Acid SCHEMBL23132693 | 0.91 | RORC (1.00) | ALBRORCPTPN1GPBAR1USP2 | |
| Betulinic Acid SCHEMBL13814590 | 0.91 | RORC (1.00) | ALBRORCPTPN1GPBAR1USP2 | |
| Betulinic Acid SCHEMBL22251646 | 0.91 | RORC (1.00) | ALBRORCPTPN1GPBAR1USP2 | |
| Betulinic Acid SCHEMBL21264235 | 0.91 | RORC (1.00) | ALBRORCPTPN1GPBAR1USP2 | |
| Betulinic Acid SCHEMBL10015159 | 0.91 | RORC (1.00) | ALBRORCPTPN1GPBAR1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110872337-B | Method for simultaneously preparing different high-purity triterpenic acids from rosemary | 湖南先伟阳光生物科技有限公司 | 2022-04-19 | — | — | CN | disclosed |
| CN-110872337-A | Method for simultaneously preparing different high-purity triterpenic acids from rosemary | 湖南先伟实业有限公司 | 2020-03-10 | — | — | CN | disclosed |
| CN-103351418-A | Semi-synthesis process of active natural compound betulinic acid | ZHANGJIAGANG WEISHENG BIOLOG PHARCEUTICAL CO LTD | 2013-10-16 | — | — | CN | disclosed |
| US-20080308426-A1 | Electrochemical Method for the Production of Betulin Aldehyde | REGENTS OF THE UNIVERSITY OF MINNESOTA | 2008-12-18 | — | — | US | disclosed |
| WO-2006105357-A2 | ELECTROCHEMICAL METHOD FOR THE PRODUCTION OF BETULIN ALDEHYDE | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2006-10-05 | — | — | WO | disclosed |
| CN-1558722-A | Feed and fertilizer containing pentacyclic triterpenes | 日清奥利友株式会社 | 2004-12-29 | — | — | CN | disclosed |