Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 4/20 | 0.34 |
| ▸ | CA1 | P00915 | 4/20 | 0.34 |
| ▸ | CA2 | P00918 | 4/20 | 0.34 |
| ▸ | CA9 | Q16790 | 4/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.32 |
| ▸ | SNCA | P37840 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | TTR | P02766 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3274968 | 0.82 | SNCA (0.39) | CA12CA1CA2CA9GPR35 | |
| SCHEMBL3036984 | 0.78 | GPR35 (0.46) | CA12CA1CA2CA9GPR35 | |
| SCHEMBL11909458 | 0.77 | VCP (0.38) | ALDH1A1MAPK1HIF1AMAPTTDP1 | |
| SCHEMBL3046926 | 0.74 | GPR35 (0.46) | CA12CA1CA2CA9GPR35 | |
| SCHEMBL6506181 | 0.73 | ATM (0.37) | ALDH1A1MAPK1HIF1AMAPTTDP1 | |
| SCHEMBL21808035 | 0.73 | HTT (0.38) | ALDH1A1SMN1; SMN2KDM4EMEN1MAPT | |
| SCHEMBL6036448 | 0.73 | ALDH1A1 (0.42) | ALDH1A1MAPK1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL28394133 | 0.69 | PKM (0.40) | ALDH1A1MAPK1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL27818989 | 0.69 | ALDH1A1 (0.33) | ALDH1A1HPGDTSHRHIF1AALOX15 | |
| SCHEMBL28738082 | 0.69 | HTT (0.38) | ALDH1A1KDM4EMEN1MAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080221120-A1 | Modulation of Aquaporin in Modulation of Angiogenesis and Cell Migration | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2008-09-11 | — | — | US | claimed |
| WO-2006102483-A2 | MODULATION OF AQUAPORIN IN MODULATON OF ANGIOGENESIS AND CELL MIGRATION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-09-28 | — | — | WO | claimed |
| US-20080221120-A1 | Modulation of Aquaporin in Modulation of Angiogenesis and Cell Migration | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2008-09-11 | — | — | US | disclosed |
| WO-2006102483-A2 | MODULATION OF AQUAPORIN IN MODULATON OF ANGIOGENESIS AND CELL MIGRATION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-09-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221120-A1 | Modulation of Aquaporin in Modulation of Angiogenesis and Cell Migration | AQP1, AQP3, AQP4 | CA12 1821/4885CA1 2140/4885CA2 397/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.