Tetrabuthylammonium

Tetrabuthylammonium

SCHEMBL492357

CCCC[N+](CCCC)(CCCC)CCCC.[Au+].[Cl-].[Cl-]

nearest known ligand 0.86

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Tetrabuthylammonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
SLC22A1 O15245 4/20 0.86
SLC22A2 O15244 1/20 0.73
ALDH1A1 P00352 1/20 0.65
TP53 P04637 1/20 0.65
CYP3A4 P08684 1/20 0.65
ALOX15 P16050 1/20 0.65
TSHR P16473 1/20 0.65
ALOX12 P18054 1/20 0.65
SMN1; SMN2 Q16637 1/20 0.65
HIF1A Q16665 1/20 0.65
HSD17B10 Q99714 1/20 0.65
DNM1 Q05193 7/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tetrabuthylammonium SCHEMBL5841582 0.96 SLC22A1 (0.92) SLC22A1SLC22A2ALDH1A1TP53CYP3A4
Tetrabuthylammonium SCHEMBL29119812 0.96 SLC22A1 (0.92) SLC22A1SLC22A2ALDH1A1TP53CYP3A4
Tetrabuthylammonium SCHEMBL1473709 0.96 SLC22A1 (0.92) SLC22A1SLC22A2ALDH1A1TP53CYP3A4
Tetrabuthylammonium SCHEMBL28454683 0.96 SLC22A1 (0.92) SLC22A1SLC22A2ALDH1A1TP53CYP3A4
Tetrabuthylammonium SCHEMBL9117 0.96 SLC22A1 (0.92) SLC22A1SLC22A2ALDH1A1TP53CYP3A4
Tetrabuthylammonium SCHEMBL23202726 0.93 SLC22A1 (0.86) SLC22A1SLC22A2ALDH1A1TP53CYP3A4
Tetrabuthylammonium SCHEMBL202211 0.93 SLC22A1 (0.86) SLC22A1SLC22A2ALDH1A1TP53CYP3A4
Hydrochloric Acid SCHEMBL9743033 0.93 SLC22A1 (0.86) SLC22A1SLC22A2ALDH1A1TP53CYP3A4
Tetrabuthylammonium SCHEMBL3169337 0.93 SLC22A1 (0.86) SLC22A1SLC22A2ALDH1A1TP53CYP3A4
Hydrochloric Acid SCHEMBL5087251 0.93 SLC22A1 (0.86) SLC22A1SLC22A2ALDH1A1TP53CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11773120-B2 Method for producing optically active 2, 3-bisphosphinopyrazine derivative and method for producing optically active phosphine transition metal complex NIPPON CHEMICAL INDUSTRIAL CO., LTD. (JP) 2023-10-03 US disclosed
CN-112585149-B Phosphine transition metal complex, process for producing the same, and anticancer agent 日本化学工业株式会社 2023-08-11 CN disclosed
US-11180516-B2 Phosphine transition metal complex, method for producing same, and anticancer agent NIPPON CHEMICAL INDUSTRIAL CO., LTD. (JP) 2021-11-23 US disclosed
US-20210253612-A1 PHOSPHINE TRANSITION METAL COMPLEX, METHOD FOR PRODUCING SAME, AND ANTICANCER AGENT NIPPON CHEMICAL INDUSTRIAL CO., LTD. (JP) 2021-08-19 US disclosed
US-11021500-B2 Process for preparing optically active 2,3-bisphosphino-substituted quinoxalines NIPPON CHEMICAL INDUSTRIAL CO., LTD. (JP) 2021-06-01 US disclosed
CN-112585149-A Phosphine transition metal complex, method for producing same, and anticancer agent 日本化学工业株式会社 2021-03-30 CN disclosed
US-20200247833-A1 METHOD FOR PRODUCING 2,3-BISPHOSPHINOPYRAZINE DERIVATIVE, AND METHOD FOR PRODUCING PHOSPHINE TRANSITION METAL COMPLEX NIPPON CHEMICAL INDUSTRIAL CO., LTD. (JP) 2020-08-06 US disclosed
WO-2020071241-A1 PHOSPHINE TRANSITION METAL COMPLEX, METHOD FOR PRODUCING SAME AND ANTITUMOR AGENT 日本化学工業株式会社 2020-04-09 WO disclosed
US-20200087330-A1 METHOD FOR PRODUCING OPTICALLY ACTIVE 2, 3-BISPHOSPHINOPYRAZINE DERIVATIVE AND METHOD FOR PRODUCING OPTICALLY ACTIVE PHOSPHINE TRANSITION METAL COMPLEX NIPPON CHEMICAL INDUSTRIAL CO., LTD. (JP) 2020-03-19 US disclosed
US-10111892-B2 Anti-cancer agent NIPPON CHEMICAL INDUSTRIAL CO., LTD. (JP) 2018-10-30 US disclosed
US-8106186-B2 Transition metal phosphine complex, method for producing same, and anticancer agent containing transition metal phospine complex NIPPON CHEMICAL INDUSTRIAL CO., LTD. (JP) 2012-01-31 US disclosed
EP-2030978-B1 PHOSPHINE TRANSITION METAL COMPLEX, METHOD FOR PRODUCING THE SAME AND ANTITUMOR AGENT NIPPON CHEMICAL IND (JP) 2011-06-29 EP disclosed
US-20100048894-A1 PHOSPHINE TRANSITION METAL COMPLEX, PROCESS FOR PRODUCING SAME, AND ANTICANCER AGENT NIPPON CHEMICAL INDUSTRIAL CO., LTD. (JP) 2010-02-25 US disclosed
US-7655810-B2 Phosphine transition metal complex, method for producing the same, and antitumor agent containing the same NIPPON CHEMICAL INDUSTRIAL CO., LTD. (JP) 2010-02-02 US disclosed
US-20090156850-A1 PHOSPHINE TRANSITION METAL COMPLEX, METHOD FOR PRODUCING THE SAME, AND ANTITUMOR AGENT CONTAINING THE SAME NIPPON CHEMICAL INDUSTRIAL CO., LTD. (JP) 2009-06-18 US disclosed
US-20090076267-A1 TRANSITION METAL PHOSPHINE COMPLEX, METHOD FOR PRODUCING SAME, AND ANTICANCER AGENT CONTAINING TRANSITION METAL PHOSPINE COMPLEX NIPPON CHEMICAL INDUSTRIAL CO., LTD. (JP) 2009-03-19 US disclosed
EP-2030978-A1 PHOSPHINE TRANSITION METAL COMPLEX, METHOD FOR PRODUCING THE SAME AND ANTITUMOR AGENT Nippon Chemical Industrial Co., Ltd. (JP) 2009-03-04 EP disclosed
EP-1958951-A1 PHOSPHINE TRANSITION METAL COMPLEX, METHOD FOR PRODUCING SAME AND ANTITUMOR AGENT CONTAINING SAME Nippon Chemical Industrial Co., Ltd. (JP) 2008-08-20 EP disclosed
US-7390915-B1 Phosphine transition metal complex having ferrocene skeleton, process for making the same, and anti-cancer agent NIPPON CHEMICAL INDUSTRIAL CO., LTD (JP) 2008-06-24 US disclosed
EP-1876182-A1 PHOSPHINE TRANSITION METAL COMPLEX, PROCESS FOR PRODUCING THE SAME AND ANTICANCER DRUG CONTAINING THE SAME Nippon Chemical Industrial Co., Ltd. (JP) 2008-01-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090076267-A1 TRANSITION METAL PHOSPHINE COMPLEX, METHOD FOR PRODUCING SAME, AND ANTICANCER AGENT CONTAINING TRANSITION METAL PHOSPINE COMPLEX CDKL1, MASTL, AARS1 SLC22A1 2511/4885SLC22A2 2700/4885ALDH1A1 2521/4885
US-20090156850-A1 PHOSPHINE TRANSITION METAL COMPLEX, METHOD FOR PRODUCING THE SAME, AND ANTITUMOR AGENT CONTAINING THE SAME PDCD1, PHOSPHO1, MCL1 SLC22A1 1466/4885SLC22A2 1861/4885ALDH1A1 1445/4885
US-11773120-B2 Method for producing optically active 2, 3-bisphosphinopyrazine derivative and method for producing optically active phosphine transition metal complex INPP5D, INPP5B, DHPS SLC22A1 1663/4885SLC22A2 1525/4885ALDH1A1 3243/4885
US-20200247833-A1 METHOD FOR PRODUCING 2,3-BISPHOSPHINOPYRAZINE DERIVATIVE, AND METHOD FOR PRODUCING PHOSPHINE TRANSITION METAL COMPLEX BPGM, PPIP5K2, BMP2 SLC22A1 1103/4885SLC22A2 856/4885ALDH1A1 2388/4885
US-20100048894-A1 PHOSPHINE TRANSITION METAL COMPLEX, PROCESS FOR PRODUCING SAME, AND ANTICANCER AGENT MCL1, IDH1, HCCS SLC22A1 978/4885SLC22A2 1602/4885ALDH1A1 2476/4885
US-11021500-B2 Process for preparing optically active 2,3-bisphosphino-substituted quinoxalines PPIP5K2, DHPS, BPGM SLC22A1 1986/4885SLC22A2 1657/4885ALDH1A1 2105/4885
US-11180516-B2 Phosphine transition metal complex, method for producing same, and anticancer agent PRMT9, MCL1, MRPS9 SLC22A1 2616/4885SLC22A2 3035/4885ALDH1A1 3878/4885
US-10111892-B2 Anti-cancer agent MCL1, ROS1, SRSF1 SLC22A1 1424/4885SLC22A2 2690/4885ALDH1A1 703/4885
US-20200087330-A1 METHOD FOR PRODUCING OPTICALLY ACTIVE 2, 3-BISPHOSPHINOPYRAZINE DERIVATIVE AND METHOD FOR PRODUCING OPTICALLY ACTIVE PHOSPHINE TRANSITION METAL COMPLEX INPP5D, INPP5B, DHPS SLC22A1 1663/4885SLC22A2 1525/4885ALDH1A1 3243/4885
US-20210253612-A1 PHOSPHINE TRANSITION METAL COMPLEX, METHOD FOR PRODUCING SAME, AND ANTICANCER AGENT PRMT9, MCL1, MRPS9 SLC22A1 2616/4885SLC22A2 3035/4885ALDH1A1 3878/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.