Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | MCOLN2 | Q8IZK6 | 4/20 | 0.48 |
| ▸ | MCOLN1 | Q9GZU1 | 4/20 | 0.48 |
| ▸ | MCOLN3 | Q8TDD5 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 4/20 | 0.47 |
| ▸ | MMP13 | P45452 | 4/20 | 0.47 |
| ▸ | MMP9 | P14780 | 3/20 | 0.47 |
| ▸ | MMP14 | P50281 | 3/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 2/20 | 0.46 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL49324 | 1.00 | ALDH1A1 (0.49) | ALDH1A1MCOLN2MCOLN1MCOLN3GAA | |
| SCHEMBL27694744 | 0.89 | ADAM17 (0.53) | ALDH1A1MCOLN2MCOLN1MCOLN3GAA | |
| SCHEMBL27676230 | 0.89 | ADAM17 (0.53) | ALDH1A1MCOLN2MCOLN1MCOLN3GAA | |
| SCHEMBL48288 | 0.89 | ADAM17 (0.53) | ALDH1A1MCOLN2MCOLN1MCOLN3GAA | |
| SCHEMBL48870 | 0.89 | ADAM17 (0.53) | ALDH1A1MCOLN2MCOLN1MCOLN3GAA | |
| SCHEMBL49184 | 0.85 | MMP2 (0.63) | ALDH1A1MCOLN2MCOLN1GAANPSR1 | |
| SCHEMBL49193 | 0.85 | MMP2 (0.63) | ALDH1A1MCOLN2MCOLN1GAANPSR1 | |
| SCHEMBL49185 | 0.85 | MMP2 (0.63) | ALDH1A1MCOLN2MCOLN1GAANPSR1 | |
| SCHEMBL49298 | 0.84 | MCOLN2 (0.38) | ALDH1A1MCOLN2MCOLN1MCOLN3GAA | |
| SCHEMBL48635 | 0.82 | MMP2 (0.69) | ALDH1A1GAANPSR1MMP2MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129406-B2 | Nonpeptide inhibitors of matrix metalloproteinases | SOUTHERN RESEARCH INSTITUTE (US) | 2012-03-06 | — | — | US | disclosed |
| EP-1735274-B1 | NONPEPTIDE INHIBITORS OF MATRIX METALLOPROTEINASES | SOUTHERN RES INST (US) | 2009-11-25 | — | — | EP | disclosed |
| US-20080312329-A1 | Nonpeptide Inhibitors of Matrix Metalloproteinases | SOUTHERN RESEARCH INSTITUTE (US) | 2008-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312329-A1 | Nonpeptide Inhibitors of Matrix Metalloproteinases | MMP1, MMP3, MMP10 | ALDH1A1 918/4885MCOLN2 1821/4885MCOLN1 812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.