SCHEMBL4944299 — predicted protein targets

Known targets — ChEMBL curated mechanism

ABL1 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB2 AGTR1 BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L2 BCR BRAF CHRM1 CHRNA10 CHRNA9 DRD1 DRD2 DRD3 DRD4 DRD5 EGFR F2 FLT1 FLT4 GCK GHSR GNRHR GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRIN3A GRIN3B HTR1A HTR1B HTR1D HTR2A HTR2C HTR3A IDH2 KDR KIT MAOB MCL1 MTTP P P4HB PDGFRB PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIKFYVE ROCK1 ROCK2 SLC18A2 SLC6A2 SLC6A3 SLC6A4 TACR1 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3E TUBA4A TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 gyrA gyrB parC parE pol

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	S1PR4	O95977	1/20	0.51

▸	SLC9A1	P19634	1/20	0.49

▸	NQO2	P16083	2/20	0.48

▸	ALDH1A1	P00352	6/20	0.48

▸	HPGD	P15428	5/20	0.48

▸	KDM4E	B2RXH2	6/20	0.47

▸	GAA	P10253	2/20	0.47

▸	MEN1	O00255	2/20	0.47

▸	KMT2A	Q03164	2/20	0.47

▸	POLB	P06746	1/20	0.47

▸	LMNA	P02545	3/20	0.47

▸	PTPN1	P18031	1/20	0.46

▸	PTPN11	Q06124	1/20	0.46

▸	ERCC5	P28715	1/20	0.46

▸	FEN1	P39748	1/20	0.46

▸	MAPT	P10636	2/20	0.45

▸	MAPK1	P28482	1/20	0.45

▸	SMN1; SMN2	Q16637	1/20	0.45

▸	NPSR1	Q6W5P4	1/20	0.45

▸	MGAM	O43451	1/20	0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL4937803	0.88	ALDH1A1 (0.49)	S1PR4NQO2ALDH1A1HPGDKDM4E
SCHEMBL4942546	0.86	NQO2 (0.53)	SLC9A1NQO2ALDH1A1HPGDKDM4E
SCHEMBL4937176	0.85	SLC9A1 (0.59)	S1PR4SLC9A1ALDH1A1HPGDKDM4E
SCHEMBL4942893	0.83	ALDH1A1 (0.55)	S1PR4SLC9A1ALDH1A1HPGDKDM4E
SCHEMBL4944695	0.82	CYP1A2 (0.62)	SLC9A1ALDH1A1HPGDKDM4EMEN1
SCHEMBL4948246	0.82	RAB9A (0.54)	S1PR4SLC9A1ALDH1A1HPGDKDM4E
SCHEMBL4939604	0.81	ALDH1A1 (0.56)	SLC9A1ALDH1A1HPGDKDM4ELMNA
SCHEMBL4943698	0.80	LMNA (0.51)	SLC9A1NQO2ALDH1A1HPGDKDM4E
SCHEMBL4936806	0.80	SLC9A1 (0.61)	S1PR4SLC9A1ALDH1A1HPGDKDM4E
SCHEMBL4943798	0.80	SLC9A1 (0.61)	S1PR4SLC9A1ALDH1A1HPGDKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-7351843-B2	Furancarbonylguanidine derivatives, their preparation and pharmaceutical compositions containing them	KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR)	2008-04-01	—	—	US	disclosed
US-20070299131-A1	Furancarbonylguanidine Derivatives, Their Preparation and Pharmaceutical Compositions Containing Them	KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR)	2007-12-27	—	—	US	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20070299131-A1	Furancarbonylguanidine Derivatives, Their Preparation and Pharmaceutical Compositions Containing Them	SLC9A1, NHERF1, SLC5A1	S1PR4 2223/4885SLC9A1 1/4885NQO2 769/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.