Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 1/20 | 0.64 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | PDE4A | P27815 | 1/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.51 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.51 |
| ▸ | TUBB | P07437 | 1/20 | 0.51 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.51 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30873516 | 1.00 | PDCD1 (0.64) | PDCD1CD274ALDH1A1SMN1; SMN2PDE4A | |
| SCHEMBL11331941 | 0.97 | PDCD1 (0.59) | PDCD1CD274ALDH1A1SMN1; SMN2PDE4A | |
| SCHEMBL6444060 | 0.94 | PDCD1 (0.56) | PDCD1CD274ALDH1A1SMN1; SMN2PDE4A | |
| SCHEMBL30141008 | 0.94 | PDCD1 (0.56) | PDCD1CD274ALDH1A1SMN1; SMN2PDE4A | |
| SCHEMBL8698472 | 0.92 | ALDH1A1 (0.65) | PDCD1CD274ALDH1A1SMN1; SMN2PDE4A | |
| SCHEMBL2879297 | 0.91 | ALDH1A1 (0.57) | PDCD1CD274ALDH1A1SMN1; SMN2PDE4A | |
| SCHEMBL13907558 | 0.87 | PDCD1 (0.50) | PDCD1CD274ALDH1A1SMN1; SMN2PDE4A | |
| SCHEMBL4045055 | 0.86 | MAOA (0.57) | PDCD1CD274ALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL2087005 | 0.86 | ALDH1A1 (0.53) | PDCD1CD274ALDH1A1SMN1; SMN2PDE4A | |
| SCHEMBL10913338 | 0.85 | ALOX5 (0.49) | PDCD1CD274ALDH1A1PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117945865-A | Bibenzyl compound and preparation method and application thereof | 中南民族大学 | 2024-04-30 | — | — | CN | claimed |
| US-20030124157-A1 | Compositions containing aromatic aldehydes and their use in treatments | ALLERGAN, INC. | 2003-07-03 | — | — | US | claimed |
| US-20240300962-A1 | Isoquinoline Derivatives, Methods of Synthesis and Uses Thereof | PROSETTA BIOSCIENCES INC (US) | 2024-09-12 | — | — | US | disclosed |
| US-12024521-B2 | Isoquinoline derivatives, methods of synthesis and uses thereof | PROSETTA BIOSCIENCES, INC. (US) | 2024-07-02 | — | — | US | disclosed |
| US-12024521-B2 | Isoquinoline derivatives, methods of synthesis and uses thereof | PROSETTA BIOSCIENCES, INC. (US) | 2024-07-02 | — | — | US | disclosed |
| US-12024521-B2 | Isoquinoline derivatives, methods of synthesis and uses thereof | PROSETTA BIOSCIENCES, INC. (US) | 2024-07-02 | — | — | US | disclosed |
| CN-117945865-A | Bibenzyl compound and preparation method and application thereof | 中南民族大学 | 2024-04-30 | — | — | CN | disclosed |
| EP-4149471-A1 | ISOQUINOLINE DERIVATIVES, METHODS OF SYNTHESIS AND USES THEREOF | Prosetta Biosciences, Inc. (US) | 2023-03-22 | — | — | EP | disclosed |
| WO-2022006228-A1 | ISOQUINOLINE DERIVATIVES, METHODS OF SYNTHESIS AND USES THEREOF | PROSETTA BIOSCIENCES, INC. (US) | 2022-01-06 | — | — | WO | disclosed |
| WO-2022006228-A1 | ISOQUINOLINE DERIVATIVES, METHODS OF SYNTHESIS AND USES THEREOF | PROSETTA BIOSCIENCES, INC. (US) | 2022-01-06 | — | — | WO | disclosed |
| US-20210403477-A1 | Isoquinoline Derivatives, Methods of Synthesis and Uses Thereof | PROSETTA BIOSCIENCES, INC. | 2021-12-30 | — | — | US | disclosed |
| US-20050222418-A1 | Novel tyloindicines and related processes, pharmaceutical compositions and methods | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-10-06 | — | — | US | disclosed |
| EP-1482937-A2 | NOVEL TYLOINDICINES AND RELATED PROCESSES, PHARMACEUTICAL COMPOSITIONS AND METHODS | YALE UNIVERSITY (US) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003070166-A2 | NOVEL TYLOINDICINES AND RELATED PROCESSES, PHARMACEUTICAL COMPOSITIONS AND METHODS | YALE UNIVERSITY (US) | 2003-08-28 | — | — | WO | disclosed |
| US-20030124157-A1 | Compositions containing aromatic aldehydes and their use in treatments | ALLERGAN, INC. | 2003-07-03 | — | — | US | disclosed |
| EP-1081149-B1 | PYRAZOLO 1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 2003-04-02 | — | — | EP | disclosed |
| US-6372749-B1 | PHARMACOLOGICAL EFFECTS SUCH AS ANALGESIC ACTION, INHIBITORY EFFECT ON NITROGEN MONOXIDE SYNTHETASE AND THE LIKE AND ARE USEFUL AS ANALGESICS. | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2002-04-16 | — | — | US | disclosed |
| EP-1081149-A1 | PYRAZOLO 1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2001-03-07 | — | — | EP | disclosed |
| US-6017916-A | Nonpeptide endothelin antagonists I | WARNER-LAMBERT COMPANY (US) | 2000-01-25 | — | — | US | disclosed |
| US-5691373-A | TREATING SUBARACHNOID HEMORRHAGE | WARNER-LAMBERT COMPANY (US) | 1997-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12024521-B2 | Isoquinoline derivatives, methods of synthesis and uses thereof | POLRMT, MAVS, SYNCRIP | PDCD1 2844/4885CD274 4325/4885ALDH1A1 3238/4885 |
| US-20030124157-A1 | Compositions containing aromatic aldehydes and their use in treatments | TYR, ALDH2, AOX1 | PDCD1 841/4885CD274 1029/4885ALDH1A1 4/4885 |
| US-20210403477-A1 | Isoquinoline Derivatives, Methods of Synthesis and Uses Thereof | POLRMT, MAVS, SYNCRIP | PDCD1 2844/4885CD274 4325/4885ALDH1A1 3238/4885 |
| US-20240300962-A1 | Isoquinoline Derivatives, Methods of Synthesis and Uses Thereof | POLRMT, MAVS, SYNCRIP | PDCD1 2844/4885CD274 4325/4885ALDH1A1 3238/4885 |
| US-20050222418-A1 | Novel tyloindicines and related processes, pharmaceutical compositions and methods | IRF3, ILF3, ATL3 | PDCD1 2285/4885CD274 2834/4885ALDH1A1 4029/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.