SCHEMBL4954471

SCHEMBL4954471

O=[C]OCc1ccc2c(c1)C(=O)c1ccccc1C2=O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 5/20 0.56
RAB9A P51151 5/20 0.56
MAPT P10636 5/20 0.56
ALDH1A1 P00352 4/20 0.56
MAPK1 P28482 4/20 0.56
SMN1; SMN2 Q16637 4/20 0.56
LMNA P02545 3/20 0.56
L3MBTL1 Q9Y468 2/20 0.56
HSP90AB1 P08238 2/20 0.45
ELANE P08246 1/20 0.43
TP53 P04637 1/20 0.43
CYP3A4 P08684 1/20 0.43
TSHR P16473 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
CDC25B P30305 1/20 0.41
BCL2 P10415 1/20 0.41
MCL1 Q07820 1/20 0.41
CYP1A2 P05177 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2601919 0.79 RAB9A (0.65) NPC1RAB9AMAPTALDH1A1MAPK1
SCHEMBL15082755 0.76 NPC1 (0.61) NPC1RAB9AMAPTALDH1A1MAPK1
SCHEMBL4954480 0.76 NPC1 (0.56) NPC1RAB9AMAPTALDH1A1MAPK1
SCHEMBL2601920 0.76 NPC1 (0.56) NPC1RAB9AMAPTALDH1A1MAPK1
SCHEMBL599540 0.76 MAPT (0.56) NPC1RAB9AMAPTALDH1A1MAPK1
SCHEMBL1307495 0.76 ALDH1A1 (0.41) NPC1RAB9AMAPTALDH1A1MAPK1
SCHEMBL1903357 0.76 TSHR (0.48) NPC1RAB9AMAPTALDH1A1MAPK1
SCHEMBL599541 0.75 MAPT (0.56) NPC1RAB9AMAPTALDH1A1MAPK1
SCHEMBL18015979 0.75 NPC1 (0.59) NPC1RAB9AMAPTALDH1A1MAPK1
SCHEMBL27590795 0.74 NPC1 (0.96) NPC1RAB9AMAPTALDH1A1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4168778-A1 METHOD FOR LOCATING INDIVIDUAL MOLECULES OF A DYE IN A SPECIMEN AND FOR GENERATING HIGH-RESOLUTION IMAGES OF A STRUCTURE IN A SPECIMEN Abberior Instruments GmbH (DE) 2023-04-26 EP claimed
WO-2021259967-A1 METHOD FOR LOCATING INDIVIDUAL MOLECULES OF A DYE IN A SPECIMEN AND FOR GENERATING HIGH-RESOLUTION IMAGES OF A STRUCTURE IN A SPECIMEN ABBERIOR INSTRUMENTS GMBH (DE) 2021-12-30 WO claimed
US-7175961-B2 Photopatternable molecular circuitry HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (US) 2007-02-13 US claimed
US-7144683-B2 Photopatternable molecular circuitry HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (US) 2006-12-05 US claimed
US-20040122233-A1 Photopatternable molecular circuitry BECK PATRICIA A (US) 2004-06-24 US claimed
US-20030194630-A1 Photopatternable molecular circuitry HEWLETT-PACKARD DEVELOPMENT COMPANY L.P. 2003-10-16 US claimed
US-20230092024-A1 Increasing Efficiency Of Photochemical Reactions On Substrates CENTRILLION TECHNOLOGIES, INC. 2023-03-23 US disclosed
WO-2021117680-A1 BIOLOGICAL SUBSTANCE IMMOBILIZATION MATERIAL 国立大学法人 東京大学 2021-06-17 WO disclosed
EP-3802847-A1 INCREASING EFFICIENCY OF PHOTOCHEMICAL REACTIONS ON SUBSTRATES Centrillion Technologies, Inc. (US) 2021-04-14 EP disclosed
CN-112533695-A Enhancing efficiency of photochemical reactions on a substrate 生捷科技控股公司 2021-03-19 CN disclosed
US-20200397901-A1 PHOTORESPONSIVE SMOOTHENED LIGAND THE UNIVERSITY OF TOKYO (JP) 2020-12-24 US disclosed
US-20200190067-A1 PHOTO-SWITCHABLE CHEMICAL INDUCERS OF DIMERIZATION FOR CONTROL OF PROTEIN FUNCTION IN CELLS BY LIGHT MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V. (DE) 2020-06-18 US disclosed
EP-3649122-A1 PHOTO-SWITCHABLE CHEMICAL INDUCERS OF DIMERIZATION FOR CONTROL OF PROTEIN FUNCTION IN CELLS BY LIGHT Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2020-05-13 EP disclosed
WO-2007025244-A2 TREATMENT SYSTEMS FOR DELIVERY OF SENSITIZER SOLUTIONS HOULE PHILIP R (US) 2007-03-01 WO disclosed
US-7175961-B2 Photopatternable molecular circuitry HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (US) 2007-02-13 US disclosed
US-7144683-B2 Photopatternable molecular circuitry HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (US) 2006-12-05 US disclosed
EP-1071821-A4 METHODS FOR REDUCING NON-SPECIFIC BINDING TO A NUCLEIC ACID PROBE ARRAY AFFYMETRIX INC (US) 2005-06-29 EP disclosed
US-20010049108-A1 Methods for reducing non-specific binding to an oligonucleotide array MCGALL GLENN (US) 2001-12-06 US disclosed
EP-1071821-A1 METHODS FOR REDUCING NON-SPECIFIC BINDING TO A NUCLEIC ACID PROBE ARRAY Affymetrix, Inc. (a California Corporation) (US) 2001-01-31 EP disclosed
WO-1999054509-A1 METHODS FOR REDUCING NON-SPECIFIC BINDING TO A NUCLEIC ACID PROBE ARRAY AFFYMETRIX, INC. (US) 1999-10-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200397901-A1 PHOTORESPONSIVE SMOOTHENED LIGAND SMO, GLI1, SHH NPC1 4603/4885RAB9A 3570/4885MAPT 4450/4885
US-20040122233-A1 Photopatternable molecular circuitry CDH1, VIM, CAT NPC1 4871/4885RAB9A 1341/4885MAPT 159/4885
US-20230092024-A1 Increasing Efficiency Of Photochemical Reactions On Substrates TYR, PCNA, DNMT1 NPC1 2643/4885RAB9A 2898/4885MAPT 502/4885
US-20010049108-A1 Methods for reducing non-specific binding to an oligonucleotide array DCLRE1B, CD2BP2, NT5C3B NPC1 3484/4885RAB9A 4858/4885MAPT 4840/4885
US-20200190067-A1 PHOTO-SWITCHABLE CHEMICAL INDUCERS OF DIMERIZATION FOR CONTROL OF PROTEIN FUNCTION IN CELLS BY LIGHT EDF1, ARFGEF1, PPIG NPC1 4592/4885RAB9A 3876/4885MAPT 1140/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.