SCHEMBL4954480

SCHEMBL4954480

O=COCc1ccc2c(c1)C(=O)c1ccccc1C2=O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 5/20 0.56
RAB9A P51151 5/20 0.56
MAPK1 P28482 4/20 0.56
ALDH1A1 P00352 4/20 0.56
SMN1; SMN2 Q16637 4/20 0.56
MAPT P10636 4/20 0.56
LMNA P02545 3/20 0.56
L3MBTL1 Q9Y468 2/20 0.56
HSP90AB1 P08238 2/20 0.45
CYP1A2 P05177 1/20 0.43
ELANE P08246 1/20 0.43
TP53 P04637 1/20 0.43
CYP3A4 P08684 1/20 0.43
TSHR P16473 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
CDC25B P30305 1/20 0.41
BCL2 P10415 1/20 0.41
MCL1 Q07820 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2601919 0.79 RAB9A (0.65) NPC1RAB9AMAPK1ALDH1A1SMN1; SMN2
SCHEMBL4954471 0.76 NPC1 (0.56) NPC1RAB9AMAPK1ALDH1A1SMN1; SMN2
SCHEMBL15082755 0.76 NPC1 (0.61) NPC1RAB9AMAPK1ALDH1A1SMN1; SMN2
SCHEMBL599540 0.76 MAPT (0.56) NPC1RAB9AMAPK1ALDH1A1SMN1; SMN2
SCHEMBL2601920 0.76 NPC1 (0.56) NPC1RAB9AMAPK1ALDH1A1SMN1; SMN2
SCHEMBL1310566 0.76 GPR84 (0.44) NPC1RAB9AMAPK1ALDH1A1SMN1; SMN2
SCHEMBL1903359 0.76 GPR84 (0.50) NPC1RAB9AMAPK1ALDH1A1SMN1; SMN2
SCHEMBL12052835 0.75 MAPT (0.48) NPC1RAB9AALDH1A1SMN1; SMN2MAPT
SCHEMBL18015979 0.75 NPC1 (0.59) NPC1RAB9AMAPK1ALDH1A1SMN1; SMN2
SCHEMBL599541 0.75 MAPT (0.56) NPC1RAB9AMAPK1ALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4168778-A1 METHOD FOR LOCATING INDIVIDUAL MOLECULES OF A DYE IN A SPECIMEN AND FOR GENERATING HIGH-RESOLUTION IMAGES OF A STRUCTURE IN A SPECIMEN Abberior Instruments GmbH (DE) 2023-04-26 EP claimed
WO-2021259967-A1 METHOD FOR LOCATING INDIVIDUAL MOLECULES OF A DYE IN A SPECIMEN AND FOR GENERATING HIGH-RESOLUTION IMAGES OF A STRUCTURE IN A SPECIMEN ABBERIOR INSTRUMENTS GMBH (DE) 2021-12-30 WO claimed
US-7175961-B2 Photopatternable molecular circuitry HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (US) 2007-02-13 US claimed
US-7144683-B2 Photopatternable molecular circuitry HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (US) 2006-12-05 US claimed
US-20040122233-A1 Photopatternable molecular circuitry BECK PATRICIA A (US) 2004-06-24 US claimed
US-20030194630-A1 Photopatternable molecular circuitry HEWLETT-PACKARD DEVELOPMENT COMPANY L.P. 2003-10-16 US claimed
US-20230092024-A1 Increasing Efficiency Of Photochemical Reactions On Substrates CENTRILLION TECHNOLOGIES, INC. 2023-03-23 US disclosed
WO-2021117680-A1 BIOLOGICAL SUBSTANCE IMMOBILIZATION MATERIAL 国立大学法人 東京大学 2021-06-17 WO disclosed
EP-3802847-A1 INCREASING EFFICIENCY OF PHOTOCHEMICAL REACTIONS ON SUBSTRATES Centrillion Technologies, Inc. (US) 2021-04-14 EP disclosed
US-20200190067-A1 PHOTO-SWITCHABLE CHEMICAL INDUCERS OF DIMERIZATION FOR CONTROL OF PROTEIN FUNCTION IN CELLS BY LIGHT MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V. (DE) 2020-06-18 US disclosed
EP-3649122-A1 PHOTO-SWITCHABLE CHEMICAL INDUCERS OF DIMERIZATION FOR CONTROL OF PROTEIN FUNCTION IN CELLS BY LIGHT Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2020-05-13 EP disclosed
WO-2019008175-A1 PHOTO-SWITCHABLE CHEMICAL INDUCERS OF DIMERIZATION FOR CONTROL OF PROTEIN FUNCTION IN CELLS BY LIGHT MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2019-01-10 WO disclosed
US-20130165350-A1 SURFACE LINKERS FOR ARRAY SYNTHESIS AFFYMETRIX, INC. (US) 2013-06-27 US disclosed
WO-2007025244-A2 TREATMENT SYSTEMS FOR DELIVERY OF SENSITIZER SOLUTIONS HOULE PHILIP R (US) 2007-03-01 WO disclosed
US-7175961-B2 Photopatternable molecular circuitry HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (US) 2007-02-13 US disclosed
US-7144683-B2 Photopatternable molecular circuitry HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (US) 2006-12-05 US disclosed
EP-1071821-A4 METHODS FOR REDUCING NON-SPECIFIC BINDING TO A NUCLEIC ACID PROBE ARRAY AFFYMETRIX INC (US) 2005-06-29 EP disclosed
US-20010049108-A1 Methods for reducing non-specific binding to an oligonucleotide array MCGALL GLENN (US) 2001-12-06 US disclosed
EP-1071821-A1 METHODS FOR REDUCING NON-SPECIFIC BINDING TO A NUCLEIC ACID PROBE ARRAY Affymetrix, Inc. (a California Corporation) (US) 2001-01-31 EP disclosed
WO-1999054509-A1 METHODS FOR REDUCING NON-SPECIFIC BINDING TO A NUCLEIC ACID PROBE ARRAY AFFYMETRIX, INC. (US) 1999-10-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040122233-A1 Photopatternable molecular circuitry CDH1, VIM, CAT NPC1 4871/4885RAB9A 1341/4885MAPK1 2853/4885
US-20230092024-A1 Increasing Efficiency Of Photochemical Reactions On Substrates TYR, PCNA, DNMT1 NPC1 2643/4885RAB9A 2898/4885MAPK1 3399/4885
US-20010049108-A1 Methods for reducing non-specific binding to an oligonucleotide array DCLRE1B, CD2BP2, NT5C3B NPC1 3484/4885RAB9A 4858/4885MAPK1 4850/4885
US-20200190067-A1 PHOTO-SWITCHABLE CHEMICAL INDUCERS OF DIMERIZATION FOR CONTROL OF PROTEIN FUNCTION IN CELLS BY LIGHT EDF1, ARFGEF1, PPIG NPC1 4592/4885RAB9A 3876/4885MAPK1 4394/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.