Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CDK9 | P50750 | 3/20 | 0.39 |
| ▸ | TACR1 | P25103 | 3/20 | 0.38 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.37 |
| ▸ | REN | P00797 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.35 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | RPLP1 | P05386 | 1/20 | 0.34 |
| ▸ | RPLP0 | P05388 | 1/20 | 0.34 |
| ▸ | RPS17 | P08708 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4963032 | 0.85 | OPRM1 (0.38) | OPRM1LMNACDK9RENSLC6A1 | |
| SCHEMBL4961968 | 0.84 | LMNA (0.58) | OPRM1LMNACDK9SLC6A1SLC6A11 | |
| SCHEMBL4962054 | 0.79 | OPRM1 (0.40) | OPRM1LMNACDK9SLC6A1SLC6A11 | |
| SCHEMBL5772858 | 0.76 | TACR1 (0.39) | TACR1BRD3KCNH2SLC6A2SLC6A4 | |
| SCHEMBL4961198 | 0.76 | BRAF (0.38) | CDK9CCNT1KCNH2RPLP1RPLP0 | |
| SCHEMBL4961286 | 0.75 | SLC6A2 (0.50) | OPRM1LMNACDK9SLC6A1SLC6A11 | |
| SCHEMBL4962731 | 0.75 | TRPM8 (0.41) | CDK9RENSLC6A1SLC6A11SMN1; SMN2 | |
| SCHEMBL4963040 | 0.73 | CHRM2 (0.52) | LMNACDK9SLC6A1SLC6A11TSHR | |
| SCHEMBL4962814 | 0.73 | CHRM2 (0.52) | LMNACDK9SLC6A1SLC6A11TSHR | |
| SCHEMBL4961245 | 0.72 | MLYCD (0.41) | LMNATACR1SLC6A1SLC6A11TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758580-A4 | N-SUBSTITUTED PIPERIDINES AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2008-01-16 | — | — | EP | claimed |
| EP-1758580-A2 | N-SUBSTITUTED PIPERIDINES AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-03-07 | — | — | EP | claimed |
| WO-2006012226-A2 | N-SUBSTITUTED PIPERIDINES AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-02 | — | — | WO | claimed |
| EP-1758580-A4 | N-SUBSTITUTED PIPERIDINES AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2008-01-16 | — | — | EP | disclosed |
| EP-1758580-A2 | N-SUBSTITUTED PIPERIDINES AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2006012226-A2 | N-SUBSTITUTED PIPERIDINES AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-02 | — | — | WO | disclosed |