Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | REN | P00797 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4960546 | 0.85 | MTNR1A (0.44) | TRPM8CDK9NPC1RAB9APOLB | |
| SCHEMBL4962814 | 0.85 | CHRM2 (0.52) | TRPM8CDK9CHRM2CHRM3NPC1 | |
| SCHEMBL4963040 | 0.85 | CHRM2 (0.52) | TRPM8CDK9CHRM2CHRM3NPC1 | |
| SCHEMBL4961277 | 0.84 | POLB (0.42) | CHRM2CHRM3RAB9ASLC6A2SLC6A4 | |
| SCHEMBL4961968 | 0.79 | LMNA (0.58) | CDK9SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL4960293 | 0.78 | TRPM8 (0.50) | TRPM8CDK9NPC1RAB9AKCNH2 | |
| SCHEMBL4961292 | 0.77 | CHRM2 (0.48) | TRPM8CDK9CHRM2CHRM3NPC1 | |
| SCHEMBL4961245 | 0.76 | MLYCD (0.41) | CHRM2CHRM3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4961872 | 0.76 | SLC6A2 (0.46) | TRPM8CDK9CHRM2CHRM3NPC1 | |
| SCHEMBL4960487 | 0.75 | OPRM1 (0.39) | CDK9SLC6A2SLC6A4KCNH2REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758580-A4 | N-SUBSTITUTED PIPERIDINES AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2008-01-16 | — | — | EP | disclosed |
| EP-1758580-A2 | N-SUBSTITUTED PIPERIDINES AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2006012226-A2 | N-SUBSTITUTED PIPERIDINES AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-02 | — | — | WO | disclosed |