Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8740426 | 1.00 | MEN1 (0.35) | MEN1GAAKMT2AMAOAMAOB | |
| SCHEMBL12989005 | 0.83 | MEN1 (0.41) | MEN1GAAKMT2AMAOAMAOB | |
| SCHEMBL8529057 | 0.83 | MEN1 (0.41) | MEN1GAAKMT2AMAOAMAOB | |
| SCHEMBL8750552 | 0.83 | MEN1 (0.36) | MEN1GAAKMT2AMAOAMAOB | |
| SCHEMBL7280716 | 0.83 | MEN1 (0.41) | MEN1GAAKMT2AMAOAMAOB | |
| SCHEMBL2301202 | 0.83 | MEN1 (0.41) | MEN1GAAKMT2AMAOAMAOB | |
| SCHEMBL7357498 | 0.83 | ACHE (0.32) | — | |
| SCHEMBL7079195 | 0.82 | MEN1 (0.35) | MEN1GAAKMT2AMAOAMAOB | |
| SCHEMBL27912989 | 0.79 | MEN1 (0.35) | MEN1GAAKMT2AMAOAMAOB | |
| SCHEMBL11019775 | 0.74 | MAPT (0.39) | MEN1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470815-B1 | Selective neuronal nitric oxide synthase inhibitors | NORTHWESTERN UNIVERSITY (US) | 2008-12-30 | — | — | US | disclosed |
| US-20050159363-A1 | Selective neuronal nitric oxide synthase inhibitors | SILVERMAN RICHARD B (US) | 2005-07-21 | — | — | US | disclosed |
| US-6803486-B2 | PEPTIDOMIMETIC; N-AMINOBUTYL-N'-NITROGUANIDINE DERIVATIVES | NORTHWESTERN UNIVERSITY | 2004-10-12 | — | — | US | disclosed |
| US-20030119751-A1 | Selective neuronal nitric oxide synthase inhibitors | NORTHWESTERN UNIVERSITY | 2003-06-26 | — | — | US | disclosed |
| WO-2003000198-A2 | SELECTIVE NEURONAL NITRIC OXIDE SYNTHASE INHIBITORS | NORTHWESTERN UNIVERSITY (US) | 2003-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050159363-A1 | Selective neuronal nitric oxide synthase inhibitors | NOS1, NOS3, NOS2 | MEN1 4059/4885GAA 2689/4885KMT2A 2308/4885 |
| US-20030119751-A1 | Selective neuronal nitric oxide synthase inhibitors | NOS1, NOS3, NOS2 | MEN1 4059/4885GAA 2689/4885KMT2A 2308/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.