Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PTAFR | P25105 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4975675 | 0.86 | MKNK1 (0.47) | PTAFRNPC1RAB9APDK1ROCK2 | |
| SCHEMBL4982009 | 0.83 | MKNK1 (0.47) | PTAFR | |
| SCHEMBL4977669 | 0.81 | CYP11B1 (0.54) | ALDH1A1PTAFRMEN1KMT2APDK1 | |
| SCHEMBL1368662 | 0.77 | CYP46A1 (0.53) | CYP46A1ALDH1A1L3MBTL1PTAFRMEN1 | |
| SCHEMBL4977077 | 0.77 | CYP11B1 (0.53) | ALDH1A1PTAFRMEN1NPC1RAB9A | |
| SCHEMBL4980305 | 0.74 | KCNA5 (0.39) | NPC1RAB9A | |
| SCHEMBL4979253 | 0.74 | CYP11B2 (0.46) | — | |
| SCHEMBL4975773 | 0.74 | KCNA5 (0.39) | ALDH1A1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL4977530 | 0.72 | CYP11B1 (0.48) | — | |
| SCHEMBL4979558 | 0.72 | CYP11B2 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1993551-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007089735-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-08-09 | — | — | WO | disclosed |