SCHEMBL497818

SCHEMBL497818

C[C@H](NCc1ccccc1)C(=O)O

nearest known ligand 0.55

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 1/20 0.55
MEN1 O00255 2/20 0.51
KMT2A Q03164 2/20 0.51
MAPT P10636 2/20 0.51
POLB P06746 1/20 0.51
ALDH1A1 P00352 1/20 0.51
TSHR P16473 1/20 0.51
MEP1B Q16820 2/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
NR4A2 P43354 1/20 0.50
CD274 Q9NZQ7 1/20 0.49
LTA4H P09960 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3556483 1.00 SIGMAR1 (0.55) SIGMAR1MEN1KMT2AMAPTPOLB
SCHEMBL497817 1.00 SIGMAR1 (0.55) SIGMAR1MEN1KMT2AMAPTPOLB
Hydrochloric Acid SCHEMBL7827035 0.98 SIGMAR1 (0.53) SIGMAR1MEN1KMT2AMAPTPOLB
Hydrochloric Acid SCHEMBL29221566 0.98 SIGMAR1 (0.53) SIGMAR1MEN1KMT2AMAPTPOLB
Hydrochloric Acid SCHEMBL1026469 0.98 SIGMAR1 (0.53) SIGMAR1MEN1KMT2AMAPTPOLB
SCHEMBL28499340 0.90 ACP3 (0.51) SIGMAR1MEN1KMT2AMAPTPOLB
SCHEMBL17441374 0.89 ALDH1A1 (0.56) SIGMAR1MEN1KMT2AMAPTALDH1A1
SCHEMBL1997227 0.89 ALDH1A1 (0.56) SIGMAR1MEN1KMT2AMAPTALDH1A1
SCHEMBL24555089 0.88 LTA4H (0.57) MEN1KMT2ATSHRMEP1BLTA4H
Serine SCHEMBL28178645 0.87 ALPI (0.49) SIGMAR1MEN1KMT2APOLBTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 406 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117986222-A Biphenyl seven-membered ring compound and preparation method and application thereof 华侨大学 2024-05-07 CN claimed
EP-3994238-B1 LUBRICATING COMPOSITIONS CONTAINING BASIC ASHLESS ADDITIVES LUBRIZOL CORP (US) 2024-03-13 EP claimed
CN-117603074-A Synthesis method of 2-amino-3-phenyl-2-methylbutanoic acid compound 马鞍山诺恩特医药科技有限公司 2024-02-27 CN claimed
US-20110038952-A1 GAMBOGIC ACID GLYCOSIDE DERIVATIVES AND ANALOGS, THEIR PREPARATION METHODS AND APPLICATIONS XU LIFENG 2011-02-17 US claimed
EP-2223929-A1 GAMBOGIC GLYCOSIDE DERIVATIVES AND ANALOGS, THE PREPARATION AND THE APPLICATION THEREOF Liaoning Lifeng Scientific&Technology Development Company Ltd. (CN) 2010-09-01 EP claimed
US-20100041612-A1 Fragments of the Glucagon-Like Peptide-1 and Uses Thereof NEW ENGLAND MEDICAL CENTER HOSPITALS, INC. 2010-02-18 US claimed
WO-2007030706-A1 FRAGMENTS OF THE GLUCAGON-LIKE PEPTIDE-I AND USES THEREOF NEW ENGLAND MEDICAL CENTER HOSPITALS, INC. (US) 2007-03-15 WO claimed
WO-2025122024-A1 INJECTABLE COMPOSITIONS FOR THE POSTOPERATIVE TREATMENT OF MALIGNANT BRAIN TUMOURS Общество с ограниченной ответственностью "Нейролайт Технолоджи" 2025-06-12 WO disclosed
US-12240871-B2 Method for producing peptide compound NISSAN CHEMICAL CORPORATION (JP) 2025-03-04 US disclosed
CN-114778655-B Analysis method of amino acid derivative enantiomer structure based on natamycin 宁波大学 2025-03-04 CN disclosed
US-20240398812-A1 MODULATORS OF TRPML, THEIR COMPOSITIONS AND METHODS OF USE CARAWAY THERAPEUTICS, INC. (US) 2024-12-05 US disclosed
CN-118878461-A PD-1/PD-L1 inhibitors 吉利德科学公司 2024-11-01 CN disclosed
CN-117986222-A Biphenyl seven-membered ring compound and preparation method and application thereof 华侨大学 2024-05-07 CN disclosed
US-4837204-A RENIN INHIBITORS; HYPOTENSIVE AGENTS ABBOTT LABORATORIES (US) 1989-06-06 US disclosed
EP-0307837-A2 Renin-inhibiting peptidyl heterocycles ABBOTT LABORATORIES (US) 1989-03-22 EP disclosed
EP-0230266-A2 Functionalized peptidyl aminodiols and -triols ABBOTT LABORATORIES (US) 1987-07-29 EP disclosed
US-4069385-A FROM AN OLEFIN AND AN ORGANIC PEROXIDE WITH COPPER-SCHIFF BASE COMPEX AS CATALYST SUMITOMO CHEMICAL COMPANY, LIMITED (JA) 1978-01-17 US disclosed
US-4032567-A TRIIODOISOPHTHALIC ACID MONOAMINO ACID AMIDES, PROCESS FOR THE PREPARATION THEREOF, AND USE THEREOF AS X-RAY CONTRAST MEDIA SCHERING AKTIENGESELLSCHAFT (DT) 1977-06-28 US disclosed
US-3953501-A X-RAY CONTRAST AGENTS SCHERING AKTIENGESELLSCHAFT (DT) 1976-04-27 US disclosed
US-3943153-A BACTERICIDES MERCK & CO., INC. (US) 1976-03-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240398812-A1 MODULATORS OF TRPML, THEIR COMPOSITIONS AND METHODS OF USE MCOLN1, PKD2, MCOLN3 SIGMAR1 1970/4885MEN1 629/4885KMT2A 4393/4885
US-20110038952-A1 GAMBOGIC ACID GLYCOSIDE DERIVATIVES AND ANALOGS, THEIR PREPARATION METHODS AND APPLICATIONS PYGL, GYS2, G6PD SIGMAR1 747/4885MEN1 2652/4885KMT2A 3765/4885
US-12240871-B2 Method for producing peptide compound NGLY1, NPPA, NPEPPS SIGMAR1 4435/4885MEN1 143/4885KMT2A 3924/4885
US-20100041612-A1 Fragments of the Glucagon-Like Peptide-1 and Uses Thereof GLP1R, IAPP, GIPR SIGMAR1 3628/4885MEN1 641/4885KMT2A 4262/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.