Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.50 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.49 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.49 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2809134 | 0.92 | ALDH1A1 (0.55) | MAPTRAB9AMRGPRX4ALDH1A1CYP1A2 | |
| SCHEMBL27956214 | 0.87 | MRGPRX4 (0.56) | MAPTRAB9AMRGPRX4ALDH1A1CYP1A2 | |
| SCHEMBL6283857 | 0.86 | CYP4F2 (0.58) | MAPTRAB9AMRGPRX4ALDH1A1CYP1A2 | |
| SCHEMBL385706 | 0.86 | RAB9A (0.59) | MAPTRAB9AMRGPRX4ALDH1A1CYP1A2 | |
| SCHEMBL2340354 | 0.86 | KMT2A (0.71) | MAPTRAB9AMRGPRX4ALDH1A1CYP1A2 | |
| SCHEMBL4506029 | 0.85 | L3MBTL1 (0.60) | MAPTRAB9AKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL31536904 | 0.84 | SMPD1 (0.63) | MAPTRAB9AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL6811204 | 0.84 | SMPD1 (0.63) | MAPTRAB9AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL2087816 | 0.84 | ALDH1A1 (0.56) | MAPTRAB9AMRGPRX4ALDH1A1CYP1A2 | |
| SCHEMBL72899 | 0.84 | MRGPRX4 (0.57) | MAPTRAB9AMRGPRX4ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080027060-A1 | DIPEPTIDE NITRILES | ALTMANN EVA | 2008-01-31 | — | — | US | disclosed |
| US-20060235220-A1 | Dipeptide nitriles | MISSBACH MARTIN | 2006-10-19 | — | — | US | disclosed |
| US-20040110806-A1 | Dipeptide derivatives | ALTMANN EVA (CH) | 2004-06-10 | — | — | US | disclosed |
| US-20040029814-A1 | Dipeptide nitriles | ALTMANN EVA (CH) | 2004-02-12 | — | — | US | disclosed |
| US-6353017-B1 | INHIBITORS OF CATHESPINS USING DIPEPTIDE NITRILES AS ANTIINFLAMMATORY AGENTS AND ANTIARTHRITIC AGENTS | NOVARTIS AG (CH) | 2002-03-05 | — | — | US | disclosed |
| EP-1028942-A2 | DIPEPTIDE NITRILES | Novartis AG (CH) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999024460-A2 | DIPEPTIDE NITRILES | NOVARTIS AG (CH) | 1999-05-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110806-A1 | Dipeptide derivatives | CTSL, CTSZ, CTSS | MAPT 4532/4885RAB9A 710/4885MRGPRX4 2290/4885 |
| US-20040029814-A1 | Dipeptide nitriles | NOS1, CTSL, CTSS | MAPT 4416/4885RAB9A 1085/4885MRGPRX4 2182/4885 |
| US-20060235220-A1 | Dipeptide nitriles | CTSL, CTSS, CTSB | MAPT 4622/4885RAB9A 964/4885MRGPRX4 1383/4885 |
| US-20080027060-A1 | DIPEPTIDE NITRILES | CTSL, CTSS, CTSB | MAPT 4622/4885RAB9A 964/4885MRGPRX4 1383/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.