SCHEMBL5012806

SCHEMBL5012806

C=Cc1ccc([Si](OC)(c2ccc(C=C)cc2)c2ccc(C=C)cc2)cc1

nearest known ligand 0.50

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.50
TSHR P16473 1/20 0.39
TRPA1 O75762 1/20 0.38
HDAC8 Q9BY41 1/20 0.38
TDP1 Q9NUW8 2/20 0.34
CHRNB2 P17787 1/20 0.34
CHRNB4 P30926 1/20 0.34
CHRNA3 P32297 1/20 0.34
CHRNA7 P36544 1/20 0.34
CHRNA4 P43681 1/20 0.34
TP53 P04637 1/20 0.31
TAS1R3 Q7RTX0 1/20 0.31
TAS1R1 Q7RTX1 1/20 0.31
SLC6A2 P23975 1/20 0.31
SLC6A4 P31645 1/20 0.31
SLC6A3 Q01959 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL100085 0.82 ALDH1A1 (0.50) ALDH1A1TSHRTRPA1HDAC8TDP1
SCHEMBL5014438 0.82 ALDH1A1 (0.50) ALDH1A1TSHRTRPA1HDAC8TDP1
SCHEMBL27813923 0.82 ALDH1A1 (0.50) ALDH1A1TSHRTRPA1HDAC8TDP1
SCHEMBL1448787 0.80 ALDH1A1 (0.48) ALDH1A1TSHRTRPA1HDAC8TDP1
SCHEMBL2770905 0.80 ALDH1A1 (0.48) ALDH1A1TSHRTRPA1HDAC8TDP1
SCHEMBL15471175 0.77 ALDH1A1 (0.44) ALDH1A1TSHRTRPA1HDAC8TDP1
SCHEMBL19856497 0.77 ALDH1A1 (0.44) ALDH1A1TSHRTRPA1HDAC8TDP1
SCHEMBL2168495 0.75 ALDH1A1 (0.42) ALDH1A1TSHRTRPA1HDAC8TDP1
SCHEMBL2240468 0.75 ALDH1A1 (0.42) ALDH1A1TSHRTRPA1HDAC8TDP1
SCHEMBL5146345 0.75 ALDH1A1 (0.48) ALDH1A1TSHRTRPA1HDAC8TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7470761-B2 Proton-conductive membranes and layers and methods for their production FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG E.V. (DE) 2008-12-30 US disclosed
EP-1323767-B1 Proton conducting membranes or layers and process for their fabrication FRAUNHOFER GES FORSCHUNG (DE) 2008-03-12 EP disclosed
US-20060058485-A1 Proton-conductive membranes and layers and methods for their production FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG E.V. 2006-03-16 US disclosed
US-6984747-B2 Method for preparing styryl-functionalized silanes FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG E.V. (DE) 2006-01-10 US disclosed
US-6949616-B2 Proton-conductive membranes and layers and methods for their production FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG E.V. (DE) 2005-09-27 US disclosed
EP-1318153-B1 Process for the preparation of styrylsilanes FRAUNHOFER GES FORSCHUNG (DE) 2004-08-04 EP disclosed
US-20030144450-A1 Proton-conductive membranes and layers and methods for their production FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG E.V. 2003-07-31 US disclosed
US-20030139621-A1 Method for preparing styryl-functionalized silanes FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG E.V. 2003-07-24 US disclosed
EP-1323767-A2 Proton conducting membranes or layers and process for their fabrication Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (DE) 2003-07-02 EP disclosed
EP-1318153-A1 Process for the preparation of styrylsilanes Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (DE) 2003-06-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030139621-A1 Method for preparing styryl-functionalized silanes SPTSSB, SIRT5, EIF2B2 ALDH1A1 1324/4885TSHR 2430/4885TRPA1 2602/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.