Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5014097 | 0.75 | PPARA (0.35) | RORCUSP2ALDH1A1GAAPKM | |
| SCHEMBL29402818 | 0.69 | PPARA (0.38) | RORCUSP2ALDH1A1GAAPKM | |
| SCHEMBL29742688 | 0.69 | RORC (0.31) | RORC | |
| SCHEMBL1836944 | 0.68 | TSHR (0.48) | RORCUSP2ALDH1A1GAAPKM | |
| SCHEMBL5915809 | 0.65 | GABRA1 (0.42) | RORCUSP2ALDH1A1GAAPKM | |
| SCHEMBL30028519 | 0.64 | ALDH1A1 (0.35) | RORCUSP2ALDH1A1GAAPKM | |
| SCHEMBL15065156 | 0.63 | TSHR (0.44) | RORCUSP2ALDH1A1GAAPKM | |
| SCHEMBL6744605 | 0.63 | TSHR (0.44) | RORCUSP2ALDH1A1GAAPKM | |
| SCHEMBL2173625 | 0.63 | TSHR (0.48) | RORCUSP2ALDH1A1GAAPKM | |
| Tromethamine SCHEMBL4624515 | 0.63 | CA2 (0.37) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289041-B1 | Polymer electrolyte composition and fuel cell | SUMITOMO CHEMICAL CO (JP) | 2008-03-12 | — | — | EP | disclosed |