Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | OXTR | P30559 | 1/20 | 0.47 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7992477 | 0.87 | KDM4E (0.50) | KDM4EGAAMAPTL3MBTL1OXTR | |
| SCHEMBL4854056 | 0.86 | KDM4E (0.53) | KDM4EGAAMAPTL3MBTL1OXTR | |
| SCHEMBL1797036 | 0.86 | KDM4E (0.53) | KDM4EGAAMAPTL3MBTL1OXTR | |
| Hydrochloric Acid SCHEMBL7504260 | 0.85 | OXTR (0.49) | KDM4EGAAMAPTL3MBTL1OXTR | |
| SCHEMBL10483911 | 0.85 | KDM4E (0.49) | KDM4EGAAMAPTL3MBTL1OXTR | |
| SCHEMBL6444346 | 0.83 | KDM4E (0.60) | KDM4EGAAMAPTL3MBTL1OXTR | |
| SCHEMBL5833308 | 0.83 | KDM4E (0.50) | KDM4EGAAMAPTL3MBTL1OXTR | |
| SCHEMBL1798367 | 0.83 | KDM4E (0.50) | KDM4EGAAMAPTL3MBTL1OXTR | |
| SCHEMBL5884859 | 0.83 | KDM4E (0.50) | KDM4EGAAMAPTL3MBTL1OXTR | |
| SCHEMBL7761434 | 0.82 | KDM4E (0.65) | KDM4EGAAMAPTL3MBTL1OXTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2443090-B1 | SUBSTITUTED ENAMINOCARBONYL COMPOUNDS FOR CONTROLLING PESTS | BAYER IP GMBH (DE) | 2017-03-29 | — | — | EP | disclosed |
| EP-2049488-B1 | N'-CYANO-N-ALKYL HALIDE IMIDE AMIDE DERIVATIVES | BAYER IP GMBH (DE) | 2015-12-09 | — | — | EP | disclosed |
| EP-2004635-B1 | SUBSTITUTED ENAMINOCARBONYL COMPOUNDS | BAYER IP GMBH (DE) | 2015-09-23 | — | — | EP | disclosed |
| EP-2638010-B1 | METHOD FOR PREPARING 2,2-DIFLUOROETHYLAMINE DERIVATIVES STARTING FROM N-(2,2-DIFLUOROETHYL)PROP-2-EN-1-AMINE | BAYER IP GMBH (DE) | 2014-12-31 | — | — | EP | disclosed |
| EP-2582673-B1 | PROCESS FOR THE PREPARATION OF 2,2-DIFLUOROETHYLAMINE DERIVATIVES BY ALKYLATION WITH 2,2-DIFLUORO-1-HALOGENO-ETHANES | BAYER IP GMBH (DE) | 2014-08-06 | — | — | EP | disclosed |
| EP-2327304-B1 | Use of substituted enaminocarbonyl compounds for combating animal pests | BAYER CROPSCIENCE AG (DE) | 2014-08-06 | — | — | EP | disclosed |
| CN-102459184-B | Substituted enamino carbonyl compounds | BAYER CROPSCIENCE AG | 2014-05-07 | — | — | CN | disclosed |
| US-8586756-B2 | Process for the preparation of 2,2-difluoroethylamine derivatives starting from N-(2,2-difluoroethyl)prop-2-en-1-amine | BAYER CROPSCIENCE AG (DE) | 2013-11-19 | — | — | US | disclosed |
| US-8546577-B2 | Substituted enaminocarbonyl compounds | BAYER CROPSCIENCE AG (DE) | 2013-10-01 | — | — | US | disclosed |
| US-8466293-B2 | Process for preparing 2,2-difluoroethylamine derivatives by alkylation with 2,2-difluoroethyl-1-haloethanes | BAYER CROPSCIENCE AG (DE) | 2013-06-18 | — | — | US | disclosed |
| US-20120123130-A1 | PROCESS FOR THE PREPARATION OF 2,2-DIFLUOROETHYLAMINE DERIVATIVES STARTING FROM N-(2,2-DIFLUOROETHYL)PROP-2-EN-1-AMINE | BAYER CROPSCIENCE AG (DE) | 2012-05-17 | — | — | US | disclosed |
| CN-102459184-A | Substituted enaminocarbonyl compounds | BAYER CROPSCIENCE AG | 2012-05-16 | — | — | CN | disclosed |
| US-8138350-B2 | N′-cyano-N-halogenalkylimidamide derivatives | BAYER CROPSCIENCE AG (DE) | 2012-03-20 | — | — | US | disclosed |
| US-8106211-B2 | Substituted enaminocarbonyl compounds | BAYER CROPSCIENCE AG (DE) | 2012-01-31 | — | — | US | disclosed |
| US-20110306770-A1 | Process for preparing 2-2-difluoroethylamine derivatives by alkylation with 2-2-difluoroethyl-1-haloethanes | BAYER CROPSCIENCE AG (DE) | 2011-12-15 | — | — | US | disclosed |
| EP-2327304-A1 | Use of substituted enaminocarbonyl compounds for combating animal pests | Bayer CropScience AG (DE) | 2011-06-01 | — | — | EP | disclosed |
| US-20100324103-A1 | Substituted Enaminocarbonyl Compounds | BAYER CROPSCIENCE AG (DE) | 2010-12-23 | — | — | US | disclosed |
| EP-2264008-A1 | Substituted enaminocarbonyl compounds | Bayer CropScience AG (DE) | 2010-12-22 | — | — | EP | disclosed |
| US-20100048646-A1 | N'-Cyano-N-Halogenalkylimidamide Derivatives | BAYER CROPSCIENCE AG (DE) | 2010-02-25 | — | — | US | disclosed |
| US-20090253749-A1 | SUBSTITUTED ENAMINOCARBONYL COMPOUNDS | BAYER CROPSCIENCE AG | 2009-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110306770-A1 | Process for preparing 2-2-difluoroethylamine derivatives by alkylation with 2-2-difluoroethyl-1-haloethanes | TPO, GBA2, SSTR2 | KDM4E 3254/4885GAA 726/4885MAPT 4578/4885 |
| US-20100324103-A1 | Substituted Enaminocarbonyl Compounds | DDT, L3MBTL3, L3MBTL4 | KDM4E 2288/4885GAA 1226/4885MAPT 4237/4885 |
| US-20090253749-A1 | SUBSTITUTED ENAMINOCARBONYL COMPOUNDS | DDT, NPEPPS, L3MBTL4 | KDM4E 613/4885GAA 1096/4885MAPT 3915/4885 |
| US-20100048646-A1 | N'-Cyano-N-Halogenalkylimidamide Derivatives | NCLN, NISCH, DDT | KDM4E 2289/4885GAA 2313/4885MAPT 4742/4885 |
| US-20120123130-A1 | PROCESS FOR THE PREPARATION OF 2,2-DIFLUOROETHYLAMINE DERIVATIVES STARTING FROM N-(2,2-DIFLUOROETHYL)PROP-2-EN-1-AMINE | AFF2, AFF1, AFF4 | KDM4E 519/4885GAA 1522/4885MAPT 2934/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.