Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.35 |
| ▸ | CA2 | P00918 | 3/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9806448 | 1.00 | HSD17B10 (0.46) | HSD17B10CYP2C9ALDH1A1HPGDALOX15 | |
| SCHEMBL11723408 | 1.00 | HSD17B10 (0.46) | HSD17B10CYP2C9ALDH1A1HPGDALOX15 | |
| SCHEMBL468535 | 0.98 | — | — | |
| SCHEMBL11715929 | 0.95 | HSD17B10 (0.46) | HSD17B10CYP2C9ALDH1A1HPGDALOX15 | |
| SCHEMBL9131234 | 0.90 | — | — | |
| SCHEMBL9019642 | 0.87 | HSD17B10 (0.57) | HSD17B10CYP2C9ALDH1A1HPGDALOX15 | |
| SCHEMBL28417890 | 0.87 | HSD17B10 (0.57) | HSD17B10CYP2C9ALDH1A1HPGDALOX15 | |
| SCHEMBL9198996 | 0.84 | ALDH1A1 (0.60) | HSD17B10CYP2C9ALDH1A1HPGDALOX15 | |
| SCHEMBL27526716 | 0.79 | HSD17B10 (0.60) | HSD17B10CYP2C9ALDH1A1HPGDALOX15 | |
| SCHEMBL4560478 | 0.78 | HSD17B10 (0.48) | HSD17B10CYP2C9ALDH1A1HPGDALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3311843-A1 | COMPOSITIONS COMPRISING DITHIOCARBAMATE AND CYCLODEXTRIN | Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts (DE) | 2018-04-25 | — | — | EP | claimed |
| US-20140220152-A1 | Compositions and Methods for Detecting, Treating, or Preventing Reductive Stress | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2014-08-07 | — | — | US | claimed |
| US-20070232692-A1 | Method of Treating Cancer Using Dithiocarbamate Derivatives | THE UNIVERSITY OF UTAH | 2007-10-04 | — | — | US | claimed |
| EP-3311843-A1 | COMPOSITIONS COMPRISING DITHIOCARBAMATE AND CYCLODEXTRIN | Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts (DE) | 2018-04-25 | — | — | EP | disclosed |
| US-20140220152-A1 | Compositions and Methods for Detecting, Treating, or Preventing Reductive Stress | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2014-08-07 | — | — | US | disclosed |
| US-20120030779-A1 | COMPOSITIONS AND METHODS FOR DETECTING, TREATING, OR PREVENTING REDUCTIVE STRESS | UNIVERSITY OF UTAH RESEARCH FOUNDTION (UT) | 2012-02-02 | — | — | US | disclosed |
| US-20110206756-A1 | DITHIOCARBAMATE METAL CHELATES AND METHODS OF MAKING AND USING THEREOF | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2011-08-25 | — | — | US | disclosed |
| CN-102026625-A | Dithiocarbamate metal chelates and methods of making and using thereof | UNIV UTAH RES FOUND | 2011-04-20 | — | — | CN | disclosed |
| EP-2265256-A1 | DITHIOCARBAMATE METAL CHELATES AND METHODS OF MAKING AND USING THEREOF | University of Utah Research Foundation (US) | 2010-12-29 | — | — | EP | disclosed |
| US-7816403-B2 | Method of inhibiting ATF/CREB and cancer cell growth and pharmaceutical compositions for same | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2010-10-19 | — | — | US | disclosed |
| WO-2009117333-A1 | DITHIOCARBAMATE METAL CHELATES AND METHODS OF MAKING AND USING THEREOF | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2009-09-24 | — | — | WO | disclosed |
| US-20030229064-A1 | Method of treating cancer using dithiocarbamate derivatives | CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY D/B/A CAROLINAS MEDICAL CENTER | 2003-12-11 | — | — | US | disclosed |
| EP-1328267-A2 | METHOD OF TREATING CANCER USING DITHIOCARBAMATE DERIVATIVES | Charlotte-Mecklenburg Hospital Authority doing business as Carolinas Medical Center (US) | 2003-07-23 | — | — | EP | disclosed |
| US-6589987-B2 | Dithiocarbamate, particularly tetraethylthiuram disulfide strongly inhibits the growth of cancer cells of a variety of cell types. Such inhibitory effect is enhanced by heavy metal ions such as copper ions, cytokines and ceruloplasmin and | CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY | 2003-07-08 | — | — | US | disclosed |
| US-6548540-B2 | Administering dithiocarbamate thiolate anions to sensitize humans to conventional chemotherapy by blocking the p-glycoprotein membrane toxin extrusion pump | CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY | 2003-04-15 | — | — | US | disclosed |
| US-20030065026-A1 | METHOD OF TREATING CANCER USING TETRAETHYL THIURAM DISULFIDE | UNIVERSITY OF UTAH RESEARCH FOUNDATION | 2003-04-03 | — | — | US | disclosed |
| EP-1214063-A1 | METHOD OF TREATING CANCER USING TETRAETHYL THIURAM DISULFIDE | Charlotte-Mecklenburg Hospital Authority doing business as Carolinas Medical Center (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2002028349-A2 | METHOD OF TREATING CANCER USING DITHIOCARBAMATE DERIVATIVES | CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY, DOING BUSINESS AS CAROLINAS MEDICAL CENTER (US) | 2002-04-11 | — | — | WO | disclosed |
| US-20010016600-A1 | Method of treating cancer using dithiocarbamate derivatives | THE UNIVERSITY OF UTAH | 2001-08-23 | — | — | US | disclosed |
| WO-2001017522-A1 | METHOD OF TREATING CANCER USING TETRAETHYL THIURAM DISULFIDE | CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY DOING BUSINESS AS CAROLINAS MEDICAL CENTER (US) | 2001-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030065026-A1 | METHOD OF TREATING CANCER USING TETRAETHYL THIURAM DISULFIDE | TST, TTPA, THPO | HSD17B10 2536/4885CYP2C9 3280/4885ALDH1A1 1100/4885 |
| US-20110206756-A1 | DITHIOCARBAMATE METAL CHELATES AND METHODS OF MAKING AND USING THEREOF | DLST, DLAT, TTPA | HSD17B10 2704/4885CYP2C9 4583/4885ALDH1A1 3694/4885 |
| US-20030229064-A1 | Method of treating cancer using dithiocarbamate derivatives | TST, HCCS, SERPINC1 | HSD17B10 2110/4885CYP2C9 3214/4885ALDH1A1 1338/4885 |
| US-20120030779-A1 | COMPOSITIONS AND METHODS FOR DETECTING, TREATING, OR PREVENTING REDUCTIVE STRESS | TNNC1, TNNI3, HSPA5 | HSD17B10 1515/4885CYP2C9 3643/4885ALDH1A1 2412/4885 |
| US-20010016600-A1 | Method of treating cancer using dithiocarbamate derivatives | TST, HCCS, SERPINC1 | HSD17B10 2110/4885CYP2C9 3214/4885ALDH1A1 1338/4885 |
| US-20140220152-A1 | Compositions and Methods for Detecting, Treating, or Preventing Reductive Stress | TNNC1, TNNI3, TXN2 | HSD17B10 1082/4885CYP2C9 3328/4885ALDH1A1 1197/4885 |
| US-20070232692-A1 | Method of Treating Cancer Using Dithiocarbamate Derivatives | TST, HCCS, SERPINC1 | HSD17B10 1845/4885CYP2C9 3187/4885ALDH1A1 1236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.