Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.38 |
| ▸ | ANO2 | Q9NQ90 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5032620 | 0.90 | HPGD (0.39) | KMT2AMEN1LMNAPOLBMAPT | |
| SCHEMBL5034680 | 0.88 | MAPT (0.46) | KMT2AMEN1LMNAPOLBANO1 | |
| SCHEMBL5035310 | 0.83 | HPGD (0.40) | KMT2AMEN1LMNAPOLBMAPT | |
| SCHEMBL5035948 | 0.82 | CYP3A4 (0.40) | KMT2AMEN1LMNAMAPTHPGD | |
| SCHEMBL5041310 | 0.81 | CES2 (0.37) | KMT2AMEN1LMNAMAPTHPGD | |
| SCHEMBL5035949 | 0.81 | CYP3A4 (0.42) | KMT2AMEN1LMNAMAPTHPGD | |
| SCHEMBL5034993 | 0.79 | MEN1 (0.41) | KMT2AMEN1LMNAEPHX2TSHR | |
| SCHEMBL5032562 | 0.78 | CRHBP (0.36) | KMT2AMEN1TSHRCRHBPCRHR2 | |
| SCHEMBL5032631 | 0.78 | CYP3A4 (0.37) | KMT2AMEN1LMNAMAPTKDM4E | |
| SCHEMBL5039110 | 0.78 | CYP3A4 (0.42) | KMT2AMEN1POLBMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694673-B1 | THIAZOLE DERIVATES | HOFFMANN LA ROCHE (CH) | 2008-01-16 | — | — | EP | claimed |